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. 1980 Jul 1;152(1):219–228. doi: 10.1084/jem.152.1.219

Genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains

PMCID: PMC2185909  PMID: 6249881

Abstract

A single mendelian gene was identified for induction of the endogenous xenotropic murine leukemia virus in five mouse strains (C57BL/10, C57L, C57BR, AKR, and BALB/c). This locus, designated Bxv-1, mapped to the same site on chromosome 1 in all strains: Id-1-Pep-3-[Bxv-1-Lp]. Thus, inducibility loci for xenotropic virus are more limited in number and chromosomal distribution than ecotropic inducibility loci. Virus expression in mice with Bxv-1 was induced by treatment of fibroblasts with 5-iododeoxyuridine or by exposure of spleen cells to a B cell mitogen, bacterial lipopolysaccharide. An analysis of the hamster X mouse somatic cell hybrids indicated that chromosome 1, alone, was sufficient for virus induction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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