Abstract
A marked difference was observed in the severity of disease in lymphocytic choriomeningitis (LCM) virus-infected suckling BALB/c, Swiss, and C3H mice. BALB/c mice had minimal liver lesions and none died, whereas C3H mice had extensive liver lesions and all mice died. An intermediate pattern was oberved for Swiss mice (36% mortality). Although there was no difference in the titers of LCM virus in the plasma or liver between these three strains of mice, there was a marked difference in the amount of interferon produced and the duration of interferonemia. C3H mice produced more interferon than Swiss mice which produced more interferon than BALB/c mice, indicating a direct correlation between the amount of interferon induced by LCM virus and the extent of disease. Inoculation of a potent anti-mouse interferon globulin markedly reduced the incidence of mortality in virus-infected C3H mice. BALB/c mice were as sensitive to the effects of interferon as C3H mice because daily administration of potent interferon preparations did induce disease in this strain. This ensemble of results supports our contention that endogenous interferon is in large part responsible for the manifestaions of acute LCM virus disease in suckling mice.
Full Text
The Full Text of this article is available as a PDF (1,014.6 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Gresser I., Fontaine-Brouty-Boyé D., Bourali C., Thomas M. T. A comparison of the efficacy of endogenous, exogenous, and combined endogenous-exogenous interferon in the treatment of mice infected with encephalomyocarditis virus. Proc Soc Exp Biol Med. 1969 Jan;130(1):236–242. doi: 10.3181/00379727-130-33529. [DOI] [PubMed] [Google Scholar]
- Gresser I., Tovey M. G., Bandu M. E., Maury C., Brouty-Boyé D. Role of interferon in the pathogenesis of virus diseases in mice as demonstrated by the use of anti-interferon serum. I. Rapid evolution of encephalomyocarditis virus infection. J Exp Med. 1976 Nov 2;144(5):1305–1315. doi: 10.1084/jem.144.5.1305. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HOTCHIN J. The biology of lymphocytic choriomeningitis infection: virus-induced immune disease. Cold Spring Harb Symp Quant Biol. 1962;27:479–499. doi: 10.1101/sqb.1962.027.001.046. [DOI] [PubMed] [Google Scholar]
- Hooks J. J., Moutsopoulos H. M., Geis S. A., Stahl N. I., Decker J. L., Notkins A. L. Immune interferon in the circulation of patients with autoimmune disease. N Engl J Med. 1979 Jul 5;301(1):5–8. doi: 10.1056/NEJM197907053010102. [DOI] [PubMed] [Google Scholar]
- Ida S., Hooks J. J., Siraganian R. P., Notkins A. L. Enhancement of IgE-mediated histamine release from human basophils by viruses: role of interferon. J Exp Med. 1977 Apr 1;145(4):892–906. doi: 10.1084/jem.145.4.892. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Oldstone M. B., Dixon F. J. Change in susceptibility of C3H-HeJ mice to LCM virus infection. J Immunol. 1973 Nov;111(5):1613–1615. [PubMed] [Google Scholar]
- Popescu M., Lehmann-Grube F. Diversity of lymphocytic choriomeningitis virus: variation due to replication of the virus in the mouse. J Gen Virol. 1976 Jan;30(1):113–122. doi: 10.1099/0022-1317-30-1-113. [DOI] [PubMed] [Google Scholar]
- ROWE W. P. Protective effect of pre-irradiation on lymphocytic choriomeningitis infection in mice. Proc Soc Exp Biol Med. 1956 May;92(1):194–198. doi: 10.3181/00379727-92-22425. [DOI] [PubMed] [Google Scholar]
- Rivière Y., Gresser I., Guillon J. C., Tovey M. G. Inhibition by anti-interferon serum of lymphocytic choriomeningitis virus disease in suckling mice. Proc Natl Acad Sci U S A. 1977 May;74(5):2135–2139. doi: 10.1073/pnas.74.5.2135. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tovey M. G., Begon-Lours J., Gresser I. A method for the large scale production of potent interferon preparations. Proc Soc Exp Biol Med. 1974 Jul;146(3):809–815. doi: 10.3181/00379727-146-38196. [DOI] [PubMed] [Google Scholar]
- de Maeyer E., de Maeyer-Guignard J. Gene with quantitative effect on circulating interferon induced by Newcastle disease virus. J Virol. 1969 May;3(5):506–512. doi: 10.1128/jvi.3.5.506-512.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- de Maeyer E., de Maeyer-Guignard J., Hall W. T., Bailey D. W. A locus affecting circulating interferon levels induced by mouse mammary tumour virus. J Gen Virol. 1974 May;23(2):209–211. doi: 10.1099/0022-1317-23-2-209. [DOI] [PubMed] [Google Scholar]
- von Boehmer H., Lehmann-Grube F., Flemer R., Heuwinkel R. Multiplication of lymphocytic choriomeningitis virus in cultivated foetal inbred mouse cells and in neonatally infected inbred carrier mice. J Gen Virol. 1974 Nov;25(2):219–228. doi: 10.1099/0022-1317-25-2-219. [DOI] [PubMed] [Google Scholar]