Abstract
AKR/J thymocytes derived from fetal liver cells do not produce virus when they differentiate in lethally irradiated B10.K mice, whereas spleen and bone marrow cells are virus producers. In contrast, B10.K thymocytes that differentiate in lethally irradiated AKR mice become virus producers. These results suggest that infection of the thymus in AKR mice is initiated in thymic stromal cells.
Full Text
The Full Text of this article is available as a PDF (367.6 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Datta S. K., Schwartz R. S. Restricted expression of ecotropic virus by thymocytes of leukemia-resistant (AKR X NZB)F1 mice. J Exp Med. 1978 Jul 1;148(1):329–334. doi: 10.1084/jem.148.1.329. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Datta S. K., Waksal S. D., Schwartz R. S. Phenotypic alteration in retroviral gene expression by leukemia-resistant thymocytes differentiating in leukemia-susceptible recipients. Cell. 1980 Jan;19(1):171–179. doi: 10.1016/0092-8674(80)90398-0. [DOI] [PubMed] [Google Scholar]
- Feldman D. G., Dreyfuss Y., Gross L. Electron microscopic study of the mouse leukemia virus (Gross) in organs of mouse embryos from virus-injected and normal C3Hf parents. Cancer Res. 1967 Oct;27(10):1792–1804. [PubMed] [Google Scholar]
- GROSS L. "Spontaneous" leukemia developing in C3H mice following inoculation in infancy, with AK-leukemic extracts, or AK-embrvos. Proc Soc Exp Biol Med. 1951 Jan;76(1):27–32. [PubMed] [Google Scholar]
- Hartley J. W., Rowe W. P., Capps W. I., Huebner R. J. Isolation of naturally occurring viruses of the murine leukemia virus group in tissue culture. J Virol. 1969 Feb;3(2):126–132. doi: 10.1128/jvi.3.2.126-132.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hartley J. W., Rowe W. P. Clonal cells lines from a feral mouse embryo which lack host-range restrictions for murine leukemia viruses. Virology. 1975 May;65(1):128–134. doi: 10.1016/0042-6822(75)90013-6. [DOI] [PubMed] [Google Scholar]
- Hartley J. W., Wolford N. K., Old L. J., Rowe W. P. A new class of murine leukemia virus associated with development of spontaneous lymphomas. Proc Natl Acad Sci U S A. 1977 Feb;74(2):789–792. doi: 10.1073/pnas.74.2.789. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kawashima K., Ikeda H., Hartley J. W., Stockert E., Rowe W. P., Old L. J. Changes in expression of murine leukemia virus antigens and production of xenotropic virus in the late preleukemic period in AKR mice. Proc Natl Acad Sci U S A. 1976 Dec;73(12):4680–4684. doi: 10.1073/pnas.73.12.4680. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Koppenheffer T. L., Phillips J. H., Jr, Vankin G. L. C-type virus-lymphocyte interactions in developing mouse thymus. Am J Anat. 1978 Sep;153(1):165–170. doi: 10.1002/aja.1001530111. [DOI] [PubMed] [Google Scholar]
- Lilly F., Duran-Reynals M. L., Rowe W. P. Correlation of early murine leukemia virus titer and H-2 type with spontaneous leukemia in mice of the BALB/c times AKR cross: a genetic analysis. J Exp Med. 1975 Apr 1;141(4):882–889. [PMC free article] [PubMed] [Google Scholar]
- Pincus T., Hartley J. W., Rowe W. P. A major genetic locus affecting resistance to infection with murine leukemia viruses. I. Tissue culture studies of naturally occurring viruses. J Exp Med. 1971 Jun 1;133(6):1219–1233. doi: 10.1084/jem.133.6.1219. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pincus T., Hartley J. W., Rowe W. P. A major genetic locus affecting resistance to infection with murine leukemia viruses. IV. Dose-response relationships in Fv-1-sensitive and resistant cell cultures. Virology. 1975 Jun;65(2):333–342. doi: 10.1016/0042-6822(75)90039-2. [DOI] [PubMed] [Google Scholar]
- Rowe W. P., Pincus T. Quantitative studies of naturally occurring murine leukemia virus infection of AKR mice. J Exp Med. 1972 Feb 1;135(2):429–436. doi: 10.1084/jem.135.2.429. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rowe W. P., Pugh W. E., Hartley J. W. Plaque assay techniques for murine leukemia viruses. Virology. 1970 Dec;42(4):1136–1139. doi: 10.1016/0042-6822(70)90362-4. [DOI] [PubMed] [Google Scholar]
- Rowe W. P. Studies of genetic transmission of murine leukemia virus by AKR mice. I. Crosses with Fv-1 n strains of mice. J Exp Med. 1972 Nov 1;136(5):1272–1285. doi: 10.1084/jem.136.5.1272. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SIEGLER R., RICH M. A. UNILATERAL HISTOGENESIS OF AKR THYMIC LYMPHOMA. Cancer Res. 1963 Nov;23:1669–1678. [PubMed] [Google Scholar]
- Vernon M. L., Lane W. T., Huebner R. J. Prevalence of type-C particles in visceral tissues of embryonic and newborn mice. J Natl Cancer Inst. 1973 Oct;51(4):1171–1175. doi: 10.1093/jnci/51.4.1171. [DOI] [PubMed] [Google Scholar]
