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. 1981 Apr 1;153(4):1021–1026. doi: 10.1084/jem.153.4.1021

Adjuvant polyarthritis. V. Induction by N-acetylmuramyl-L-alanyl-D- isoglutamine, the smallest peptide subunit of bacterial peptidoglycan

PMCID: PMC2186125  PMID: 6972989

Abstract

N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP), an apparently nonimmunogenic bacterial peptidoglycan-derived small peptide, was found to induce a polyarthritis the rat similar to that induced by Freund's complete adjuvant when injected in the form of an oil emulsion. An oil emulsion of its isomer, N-acetylmuramyl-L-alanyl-L-isoglutamine, which unlike MDP has no immunostimulatory activity, failed to induce the disease.

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Selected References

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  1. Adler E., Heller H., Weiner E., Masover A., Friedman S., Lahav M., Ne'eman N., Ginsburg I. Degradation of 14 C-labeled group A streptococci and micrococci in muscular lesions in the mouse. Isr J Med Sci. 1973 Apr;9(4):483–486. [PubMed] [Google Scholar]
  2. Canty T. G., Wunderlich J. R. Quantitative in vitro assay of cytotoxic cellular immunity. J Natl Cancer Inst. 1970 Oct;45(4):761–772. [PubMed] [Google Scholar]
  3. Chang Y. H. Adjuvant polyarthritis I: incorporation of quantitative measurements of humoral and cellular immune response. J Pharmacol Exp Ther. 1977 Apr;201(1):1–7. [PubMed] [Google Scholar]
  4. Chang Y. H., Hoffman W. Adjuvant polyarthritis. III. Evidence in support of viral etiology. Arthritis Rheum. 1977 Nov-Dec;20(8):1507–1513. doi: 10.1002/art.1780200810. [DOI] [PubMed] [Google Scholar]
  5. Chang Y. H., Pearson C. M., Abe C. Adjuvant polyarthritis. IV. Induction by a synthetic adjuvant: immunologic, histopathologic, and other studies. Arthritis Rheum. 1980 Jan;23(1):62–71. doi: 10.1002/art.1780230111. [DOI] [PubMed] [Google Scholar]
  6. Chang Y. H., Pearson C. M. Pathogenesis of adjuvant arthritis in rats. Arthritis Rheum. 1978 Jan-Feb;21(1):169–170. doi: 10.1002/art.1780210133. [DOI] [PubMed] [Google Scholar]
  7. Chedid L., Audibert F., Johnson A. G. Biological activities of muramyl dipeptide, a synthetic glycopeptide analogous to bacterial immunoregulating agents. Prog Allergy. 1978;25:63–105. [PubMed] [Google Scholar]
  8. Currey H. L., Ziff M. Suppression of adjuvant disease in the rat by heterologous antilymphocyte globulin. J Exp Med. 1968 Jan 1;127(1):185–203. doi: 10.1084/jem.127.1.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ellouz F., Adam A., Ciorbaru R., Lederer E. Minimal structural requirements for adjuvant activity of bacterial peptidoglycan derivatives. Biochem Biophys Res Commun. 1974 Aug 19;59(4):1317–1325. doi: 10.1016/0006-291x(74)90458-6. [DOI] [PubMed] [Google Scholar]
  10. Koga T., Pearson C. M., Narita T., Kotani S. Polyarthritis induced in the rat with cell walls from several bacteria and two Streptomyces species. Proc Soc Exp Biol Med. 1973 Jul;143(3):824–827. doi: 10.3181/00379727-143-37421. [DOI] [PubMed] [Google Scholar]
  11. Kohashi O., Pearson C. M., Shimono T., Kotani S. Preparation of various fractions from Mycobacterium smegmatis, their arthritogenicity and their preventive effect on adjuvant disease. Int Arch Allergy Appl Immunol. 1976;51(4):451–461. doi: 10.1159/000231619. [DOI] [PubMed] [Google Scholar]
  12. Kohashi O., Pearson C. M., Watanabe Y., Kotani S., Koga T. Structural requirements for arthritogenicity of peptidoglycans from Staphylococcus aureus and Lactobacillus plant arum and analogous synthetic compounds. J Immunol. 1976 Jun;116(6):1635–1639. [PubMed] [Google Scholar]
  13. NEWBOULD B. B. ROLE OF LYMPH NODES IN ADJUVANT-INDUCED ARTHRITIS IN RATS. Ann Rheum Dis. 1964 Sep;23:392–396. doi: 10.1136/ard.23.5.392. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Nagao S., Tanaka A. Muramyl dipeptide-induced adjuvant arthritis. Infect Immun. 1980 May;28(2):624–626. doi: 10.1128/iai.28.2.624-626.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. PEARSON C. M. Development of arthritis, periarthritis and periostitis in rats given adjuvants. Proc Soc Exp Biol Med. 1956 Jan;91(1):95–101. doi: 10.3181/00379727-91-22179. [DOI] [PubMed] [Google Scholar]
  16. PEARSON C. M., WOOD F. D. PASSIVE TRANSFER OF ADJUVANT ARTHRITIS BY LYMPH NODE OR SPLEEN CELLS. J Exp Med. 1964 Oct 1;120:547–560. doi: 10.1084/jem.120.4.547. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. WAKSMAN B. H., PEARSON C. M., SHARP J. T. Studies of arthritis and other lesions induced in rats by injection of mycobacterial adjuvant. II. Evidence that the disease is a disseminated immunologic response to exogenous antigen. J Immunol. 1960 Oct;85:403–417. [PubMed] [Google Scholar]
  18. WINTER C. A., RISLEY E. A., NUSS G. W. Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. Proc Soc Exp Biol Med. 1962 Dec;111:544–547. doi: 10.3181/00379727-111-27849. [DOI] [PubMed] [Google Scholar]
  19. Wood F. D., Pearson C. M., Tanaka A. Capacity of mycobacterial wax D and its subfractions to induce adjuvant arthritis in rats. Int Arch Allergy Appl Immunol. 1969;35(5):456–467. doi: 10.1159/000230198. [DOI] [PubMed] [Google Scholar]

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