Abstract
The effect of midazolam on the field potentials (FPs) in the caudal part of the spinal trigeminal nucleus following strong electrical stimulation of the upper lip was investigated in Wistar albino rats. The rats received i.p. dosages of 5, 10, or 20 mg/kg midazolam, or physiological saline. Relative amplitudes of the negative deflection were not suppressed after midazolam injection. No significant differences were found in the latencies of the potentials before and after midazolam injection. It is suggested that the main action site of midazolam may be located at a higher level than the spinal trigeminal nucleus.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Braestrup C., Albrechtsen R., Squires R. F. High densities of benzodiazepine receptors in human cortical areas. Nature. 1977 Oct 20;269(5630):702–704. doi: 10.1038/269702a0. [DOI] [PubMed] [Google Scholar]
- Greenwood L. F., Sessle B. J. Inputs to trigeminal brain stem neurones from facial, oral, tooth pulp and pharyngolaryngeal tissues: II. Role of trigeminal nucleus caudalis in modulating responses to innocuous and noxious stimuli. Brain Res. 1976 Nov 26;117(2):227–238. doi: 10.1016/0006-8993(76)90732-0. [DOI] [PubMed] [Google Scholar]
- Shinotoh H., Yamasaki T., Inoue O., Itoh T., Hashimoto K., Tateno Y., Ikehira H., Suzuki K., Kashida Y. [A study of the benzodiazepine receptor in the human brain using 11C-Ro 15-1788 and positron emission tomography]. Kaku Igaku. 1985 Dec;22(12):1789–1797. [PubMed] [Google Scholar]
- Suzuki N., Beppu S., Uematsu H., Someya T., Kubota Y. Midazolam and somatosensory evoked potentials. Anesth Prog. 1985 Sep-Oct;32(5):199–201. [PMC free article] [PubMed] [Google Scholar]
- Toda K., Ichioka M., Iriki A., Suda H. Electroacupuncture effects on the field potentials in the caudal part of the spinal trigeminal nucleus evoked by tooth pulp stimulation in rat. Exp Neurol. 1979 Jun;64(3):704–709. doi: 10.1016/0014-4886(79)90240-1. [DOI] [PubMed] [Google Scholar]
- Toda K., Iriki A. Inhibitory actions produced by local electrical stimulation in the caudal spinal trigeminal nucleus in rat. Brain Res Bull. 1981 Aug;7(2):169–174. doi: 10.1016/0361-9230(81)90081-2. [DOI] [PubMed] [Google Scholar]