Abstract
Both sexes of the (NZW x BXSB)F1 mice developed an early systemic lupus erythematosus-like disease. In males, the disease resembled that in the BXSB male parent and was not affected by sex hormonal manipulation. In females, the disease duplicated that of (NZB x NZW)F1 females by virtue of a delayed onset and estrogen dependence. Autoantibody production, circulating Ig-bound gp 70 immune complexes, and deposition of Ig and gp 70 in the affected glomeruli were demonstrated in both males and females. The abnormally high incidence of degenerative coronary vascular disease with myocardial infarction, particularly in these F1 males, provides a useful model for the investigation of a possible immunologic component in coronary vascular disease.
Full Text
The Full Text of this article is available as a PDF (735.3 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Accinni L., Dixon F. J. Degenerative vascular disease and myocardial infarction in mice with lupus-like syndrome. Am J Pathol. 1979 Aug;96(2):477–492. [PMC free article] [PubMed] [Google Scholar]
- Andrews B. S., Eisenberg R. A., Theofilopoulos A. N., Izui S., Wilson C. B., McConahey P. J., Murphy E. D., Roths J. B., Dixon F. J. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med. 1978 Nov 1;148(5):1198–1215. doi: 10.1084/jem.148.5.1198. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bidani A. K., Roberts J. L., Schwartz M. M., Lewis E. J. Immunopathology of cardiac lesions in fatal systemic lupus erythematosus. Am J Med. 1980 Dec;69(6):849–858. doi: 10.1016/s0002-9343(80)80010-6. [DOI] [PubMed] [Google Scholar]
- Eisenberg R. A., Dixon F. J. Effect of castration on male-determined acceleration of autoimmune disease in BXSB mice. J Immunol. 1980 Nov;125(5):1959–1961. [PubMed] [Google Scholar]
- Eisenberg R. A., Izui S., McConahey P. J., Hang L., Peters C. J., Theofilopoulos A. N., Dixon F. J. Male determined accelerated autoimmune disease in BXSB mice: transfer by bone marrow and spleen cells. J Immunol. 1980 Sep;125(3):1032–1036. [PubMed] [Google Scholar]
- Howie J. B., Helyer B. J. The immunology and pathology of NZB mice. Adv Immunol. 1968;9:215–266. doi: 10.1016/s0065-2776(08)60444-7. [DOI] [PubMed] [Google Scholar]
- Izui S., Lambert P. H., Miescher P. A. Determination of anti-DNA antibodies by a modified 125I-labelled DNA-binding test. Elimination of non-specific binding of DNA to non-immunoglobulin basic proteins by using an anionic detergent. Clin Exp Immunol. 1976 Dec;26(3):425–430. [PMC free article] [PubMed] [Google Scholar]
- Izui S., McConahey P. J., Theofilopoulos A. N., Dixon F. J. Association of circulating retroviral gp70-anti-gp70 immune complexes with murine systemic lupus erythematosus. J Exp Med. 1979 May 1;149(5):1099–1116. doi: 10.1084/jem.149.5.1099. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MARSDEN P. D., HUTT M. S., WILKS N. E., VOLLER A., BLACKMAN V., SHAH K. K., CONNOR D. H., HAMILTON P. J., BANWELL J. G., LUNN H. F. AN INVESTIGATION OF TROPICAL SPLENOMEGALY AT MULAGO HOSPITAL, KAMPALA, UGANDA. Br Med J. 1965 Jan 9;1(5427):89–92. doi: 10.1136/bmj.1.5427.89. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roubinian J. R., Talal N., Greenspan J. S., Goodman J. R., Siiteri P. K. Effect of castration and sex hormone treatment on survival, anti-nucleic acid antibodies, and glomerulonephritis in NZB/NZW F1 mice. J Exp Med. 1978 Jun 1;147(6):1568–1583. doi: 10.1084/jem.147.6.1568. [DOI] [PMC free article] [PubMed] [Google Scholar]