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. 1978 Oct;136(1):136–141. doi: 10.1128/jb.136.1.136-141.1978

Evidence for an intermediate in quinolinate biosynthesis in Escherichia coli.

F D Wicks, S Sakakibara, R K Gholson
PMCID: PMC218642  PMID: 361684

Abstract

Evidence for the formation of an unstable intermediate in the synthesis of quinolinate from aspartate and dihydroxyacetone phosphate by Escherichia coli was obtained using toluenized cells of nadA and nadB mutants of this organism and partially purified A and B proteins in dialysis and membrane cone experiments. The results of these experiments indicate that the nadB gene product forms an unstable compound from aspartate in the presence of flavine adenine dinucleotide, and that this compound is then condensed with dihydroxyacetone phosphate to form quinolinate in a reaction catalyzed by the nadA gene product.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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