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. 1978 Oct;136(1):142–147. doi: 10.1128/jb.136.1.142-147.1978

Isolation and characterization of an actinomycin D-sensitive mutant of Saccharomyces cerevisiae.

C Gorenstein, K D Atkinson, E V Falkes
PMCID: PMC218643  PMID: 361685

Abstract

A single mutation in Saccharomyces cerevisiae conferred sensitivity to low concentrations of actinomycin D. Treatment with actinomycin D preferentially inhibited synthesis of rRNA's. Residual rRNA synthesized was processed normally. Total protein synthesis and inducibility of the enzyme maltase were relatively unaffected at concentrations of actinomycin D which severely inhibited rRNA synthesis.

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Selected References

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