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. 1981 Oct 1;154(4):1201–1211. doi: 10.1084/jem.154.4.1201

Genetics of susceptibility for radiation-induced leukemia. Mapping of genes involved to chromosomes 1, 2, and 4, and implications for a viral etiology in the disease

PMCID: PMC2186497  PMID: 6270228

Abstract

Susceptibility to radiation-induced leukemia in (A/J x B10)F2 mice is encoded for by genes in chromosomes 1, 2, and 4. The loci involved in chromosomes 1 and 4 are close to or similar to xenotropic virus inducibility locus on chromosome 1 and a locus-affecting expression of xenotropic MuLV envelope-related cell surface antigens. Radiation- induced leukemia-1 (Ril-1) on chromosome 2 plays an overriding influence in susceptibility to the disease. This locus might encode ecotropic viral-associated genetic information or might contain cellular sequences with oncogenic potential. These findings are of interest in view of the importance of recombinant viruses to leukemogenesis. Furthermore, it is intriguing that Ril-1 is located in a chromosomal site rich in thymus differentiation-specific loci. An explanation for tissue-specific activation of endogenous viruses is that activation of the virus in question is dependent on differentiation-specific steps.

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Selected References

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  1. AXELRAD A. A., VAN DER GAAG H. C. Susceptibility of lymphoma induction by gross' passage A virus in C3Hf/Bi mice of different ages: relation to thymic cell multiplication and differentiation. J Natl Cancer Inst. 1962 May;28:1065–1093. [PubMed] [Google Scholar]
  2. Cloyd M. W., Hartley J. W., Rowe W. P. Lymphomagenicity of recombinant mink cell focus-inducing murine leukemia viruses. J Exp Med. 1980 Mar 1;151(3):542–552. doi: 10.1084/jem.151.3.542. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Declève A., Lieberman M., Ihle J. N., Kaplan H. S. Biological and serological characterization of radiation leukemia virus. Proc Natl Acad Sci U S A. 1976 Dec;73(12):4675–4679. doi: 10.1073/pnas.73.12.4675. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Eicher E. M., Coleman D. I. Influence of gene duplication and X-inactivation on mouse mitochondrial malic enzyme activity and electrophoretic patterns. Genetics. 1977 Apr;85(4):647–658. doi: 10.1093/genetics/85.4.647. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. GROSS L. Attempt to recover filterable agent from x-ray induced leukemia. Acta Haematol. 1958 Jun;19(6):353–361. doi: 10.1159/000205455. [DOI] [PubMed] [Google Scholar]
  6. Green N., Hiai H., Elder J. H., Schwartz R. S., Khiroya R. H., Thomas C. Y., Tsichlis P. N., Coffin J. M. Expression of leukemogenic recombinant viruses associated with a recessive gene in HRS/J mice. J Exp Med. 1980 Aug 1;152(2):249–264. doi: 10.1084/jem.152.2.249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Haldane J B, Waddington C H. Inbreeding and Linkage. Genetics. 1931 Jul;16(4):357–374. doi: 10.1093/genetics/16.4.357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hartley J. W., Wolford N. K., Old L. J., Rowe W. P. A new class of murine leukemia virus associated with development of spontaneous lymphomas. Proc Natl Acad Sci U S A. 1977 Feb;74(2):789–792. doi: 10.1073/pnas.74.2.789. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Horton M. A., Hetherington C. M. Genetic linkage of Ly-6 and Thy-1 loci in the mouse. Immunogenetics. 1980;11(5):521–525. doi: 10.1007/BF01567820. [DOI] [PubMed] [Google Scholar]
  10. Hutton J. J. Linkage analyses using biochemical variants in mice. I. Linkage of the hemoglobin beta-chain and glucosephosphate isomerase loci. Biochem Genet. 1969 Oct;3(5):507–515. doi: 10.1007/BF00485611. [DOI] [PubMed] [Google Scholar]
  11. Ihle J. N., Joseph D. R., Pazmino N. H. Radiation leukemia in C57BL/6 mice. II. Lack of ecotropic virus expression in the majority of lymphomas. J Exp Med. 1976 Dec 1;144(6):1406–1423. doi: 10.1084/jem.144.6.1406. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Ihle J. N., McEwan R., Bengali K. Radiation leukemia in C57BL/6 mice. I. Lack of serological evidence for the role of endogenous ecotropic viruses in pathogenesis. J Exp Med. 1976 Dec 1;144(6):1391–1405. doi: 10.1084/jem.144.6.1391. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. KAPLAN H. S., BROWN M. B. A quantitative dose-response study of lymphoid-tumor development in irradiated C 57 black mice. J Natl Cancer Inst. 1952 Aug;13(1):185–208. [PubMed] [Google Scholar]
  14. KAPLAN H. S. The role of cell differentiation as a determinant of susceptibility to virus carcinogenesis. Cancer Res. 1961 Sep;21:981–983. [PubMed] [Google Scholar]
  15. Kaplan H. S. On the natural history of the murine leukemias: presidential address. Cancer Res. 1967 Aug;27(8):1325–1340. [PubMed] [Google Scholar]
  16. Kawashima K., Ikeda H., Hartley J. W., Stockert E., Rowe W. P., Old L. J. Changes in expression of murine leukemia virus antigens and production of xenotropic virus in the late preleukemic period in AKR mice. Proc Natl Acad Sci U S A. 1976 Dec;73(12):4680–4684. doi: 10.1073/pnas.73.12.4680. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Klein J., Shreffler D. C. The H-2 model for the major histocompatibility systems. Transplant Rev. 1971;6:3–29. doi: 10.1111/j.1600-065x.1971.tb00457.x. [DOI] [PubMed] [Google Scholar]
  18. Kozak C. A., Rowe W. P. Genetic mapping of xenotropic murine leukemia virus-inducing loci in five mouse strains. J Exp Med. 1980 Jul 1;152(1):219–228. doi: 10.1084/jem.152.1.219. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. LIEBERMAN M., KAPLAN H. S. Leukemogenic activity of filtrates from radiation-induced lymphoid tumors of mice. Science. 1959 Aug 14;130(3372):387–388. doi: 10.1126/science.130.3372.387. [DOI] [PubMed] [Google Scholar]
  20. Lewis W. H., Truslove G. M. Electrophoretic heterogeneity of mouse erythrocyte peptidases. Biochem Genet. 1969 Oct;3(5):493–498. doi: 10.1007/BF00485609. [DOI] [PubMed] [Google Scholar]
  21. Lilly F. Fv-2: identification and location of a second gene governing the spleen focus response to Friend leukemia virus in mice. J Natl Cancer Inst. 1970 Jul;45(1):163–169. [PubMed] [Google Scholar]
  22. McKenzie I. F., Potter T. Murine lymphocyte surface antigens. Adv Immunol. 1979;27:179–338. doi: 10.1016/s0065-2776(08)60263-1. [DOI] [PubMed] [Google Scholar]
  23. Meruelo D., Paolino A., Flieger N., Dworkin J., Offer M., Hirayama N., Ovary Z. Functional properties of Ly 11.2 lymphocytes: a role for these cells in leukemia? J Immunol. 1980 Dec;125(6):2719–2726. [PubMed] [Google Scholar]
  24. Meruelo D., Paolino A., Flieger N., Offer M. Definition of a new T lymphocyte cell surface antigen, Ly 11.2. J Immunol. 1980 Dec;125(6):2713–2718. [PubMed] [Google Scholar]
  25. Morse H. C., 3rd, Chused T. M., Boehm-Truitt M., Mathieson B. J., Sharrow S. O., Hartley J. W. XenCSA: cell surface antigens related to the major glycoproteins (gp70) of xenotropic murine leukemia viruses. J Immunol. 1979 Feb;122(2):443–454. [PubMed] [Google Scholar]
  26. Morse H. C., 3rd, Chused T. M., Hartley J. W., Mathieson B. J., Sharrow S. O., Taylor B. A. Expression of xenotropic murine leukemia viruses as cell-surface gp70 in genetic crosses between strains DBA/2 and C57BL/6. J Exp Med. 1979 May 1;149(5):1183–1196. doi: 10.1084/jem.149.5.1183. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Nichols E. A., Ruddle F. H. A review of enzyme polymorphism, linkage and electrophoretic conditions for mouse and somatic cell hybrids in starch gels. J Histochem Cytochem. 1973 Dec;21(12):1066–1081. doi: 10.1177/21.12.1066. [DOI] [PubMed] [Google Scholar]
  28. Varmus H. E., Quintrell N., Medeiros E., Bishop J. M., Nowinski R. C., Sarkar N. H. Transcription of mouse mammary tumor virus genes in tissues from high and low tumor incidence mouse strains. J Mol Biol. 1973 Oct 5;79(4):663–679. doi: 10.1016/0022-2836(73)90070-3. [DOI] [PubMed] [Google Scholar]

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