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. 1981 Nov 1;154(5):1709–1714. doi: 10.1084/jem.154.5.1709

Malignant lymphoma with dual B and T cell markers. Analysis of the neoplastic cells with monoclonal antibodies directed against T cell subsets

PMCID: PMC2186513  PMID: 6975352

Abstract

In the course of analyzing human lymphoma tissue with conventional surface marker techniques and with monoclonal antibodies directed against T cell subsets, five tumors were encountered with dual B and T cell determinants. All bore on their surface membrane IgM of kappa light chain type, complement receptors, and the Ia-like antigen. In each of the five cases, the neoplastic lymphocytes reacted with a monoclonal antibody that detects the sheep erythrocyte receptor (OKT11); all but one reacted with a monoclonal antibody for peripheral T cells (OKT3); and all but one reacted with a monoclonal antibody specific for either the inducer-helper (OKT4) or the cytotoxic- suppressor (OKT8) T cell subsets. In addition, lymphocytes from two of the five cases formed spontaneous rosettes with sheep erythrocytes (E- rosettes). These tumors with dual B and T surface characteristics were confined to human malignant lymphomas that originate from B lymphocytes of the follicle center.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aisenberg A. C. Current concepts in immunology: Cell-surface markers in lymphoproliferative disease. N Engl J Med. 1981 Feb 5;304(6):331–336. doi: 10.1056/NEJM198102053040606. [DOI] [PubMed] [Google Scholar]
  2. Aisenberg A. C., Wilkes B. M. Unusual human lymphoma phenotype defined by monoclonal antibody. J Exp Med. 1980 Oct 1;152(4):1126–1131. doi: 10.1084/jem.152.4.1126. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Aisenberg A. C., Wilkes B. Lymphosarcoma cell leukemia: the contribution of cell surface study to diagnosis. Blood. 1976 Nov;48(5):707–715. [PubMed] [Google Scholar]
  4. Bach J. F. Evaluation of T-cells and thymic serum factors in man using the rosette technique. Transplant Rev. 1973;16(0):196–217. doi: 10.1111/j.1600-065x.1973.tb00121.x. [DOI] [PubMed] [Google Scholar]
  5. Barrett S. G., Schwade J. G., Ranken R., Kadin M. E. Lymphoblasts with both T and B markers in childhood leukemia and lymphoma. Blood. 1977 Jul;50(1):71–79. [PubMed] [Google Scholar]
  6. Boumsell L., Coppin H., Pham D., Raynal B., Lemerle J., Dausset J., Bernard A. An antigen shared by a human T cell subset and B cell chronic lymphocytic leukemic cells. Distribution on normal and malignant lymphoid cells. J Exp Med. 1980 Jul 1;152(1):229–234. doi: 10.1084/jem.152.1.229. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Burns G. F., Nash A. A., Worman C. P., Barker C. R., Hayhoe F. G., Cawley J. C. A human leukaemic cell expressing hybrid membrane phenotypes. Nature. 1977 Jul 21;268(5617):243–245. doi: 10.1038/268243a0. [DOI] [PubMed] [Google Scholar]
  8. Dickler H. B., Adkinson N. F., Jr, Terry W. D. Evidence for individual human peripheral blood lymphocytes bearing both B and T cell markers. Nature. 1974 Jan 25;247(5438):213–215. doi: 10.1038/247213a0. [DOI] [PubMed] [Google Scholar]
  9. Foon K. A., Billing R. J., Terasaki P. I. Dual B and T markers in acute and chronic lymphocytic leukemia. Blood. 1980 Jan;55(1):16–20. [PubMed] [Google Scholar]
  10. Gatien J. G., Schneeberger E. E., Merler E. Analysis of human thymocyte subpopulations using discontinuous gradients of albumin: precursor lymphocytes in human thymus. Eur J Immunol. 1975 May;5(5):312–317. doi: 10.1002/eji.1830050505. [DOI] [PubMed] [Google Scholar]
  11. Halper J. P., Knowles D. M., 2nd, Wang C. Y. Ia antigen expression by human malignant lymphomas: correlation with conventional lymphoid markers. Blood. 1980 Mar;55(3):373–382. [PubMed] [Google Scholar]
  12. Hsu C. C., Marti G. E., Schrek R., Williams R. C., Jr Lymphocytes bearing B- and T-cell markers in patient with lymphosarcoma cell leukemia. Clin Immunol Immunopathol. 1975 Jan;3(3):385–395. doi: 10.1016/0090-1229(75)90026-4. [DOI] [PubMed] [Google Scholar]
  13. Jaffe E. S., Shevach E. M., Frank M. M., Green I. Leukemic reticuloendotheliosis: presence of a receptor for cytophilic antibody. Am J Med. 1974 Jul;57(1):108–114. doi: 10.1016/0002-9343(74)90775-x. [DOI] [PubMed] [Google Scholar]
  14. Kung P. C., Talle M. A., DeMaria M. E., Butler M. S., Lifter J., Goldstein G. Strategies for generating monoclonal antibodies defining human t-lymphocyte differentiation antigens. Transplant Proc. 1980 Sep;12(3 Suppl 1):141–146. [PubMed] [Google Scholar]
  15. Palutke M., Tabaczka P., Varadachari C., Carrillo G. 37 degrees CE rosettes in various malignant and non-malignant disorders. Br J Haematol. 1979 Nov;43(3):361–367. doi: 10.1111/j.1365-2141.1979.tb03763.x. [DOI] [PubMed] [Google Scholar]
  16. Pincus S., Bianco C., Nussenzweig V. Increased proportion of complement-receptor lymphocytes in the peripheral blood of patients with chronic lymphocytic leukemia. Blood. 1972 Sep;40(3):303–310. [PubMed] [Google Scholar]
  17. Poppema S., Bhan A. K., Reinherz E. L., McCluskey R. T., Schlossman S. F. Distribution of T cell subsets in human lymph nodes. J Exp Med. 1981 Jan 1;153(1):30–41. doi: 10.1084/jem.153.1.30. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Reinherz E. L., Kung P. C., Goldstein G., Levey R. H., Schlossman S. F. Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc Natl Acad Sci U S A. 1980 Mar;77(3):1588–1592. doi: 10.1073/pnas.77.3.1588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Royston I., Majda J. A., Baird S. M., Meserve B. L., Griffiths J. C. Human T cell antigens defined by monoclonal antibodies: the 65,000-dalton antigen of T cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin. J Immunol. 1980 Aug;125(2):725–731. [PubMed] [Google Scholar]
  20. SCHWARTZ D. L., PIERRE R. V., SCHEERER P. P., REED E. C., Jr, LINMAN J. W. LYMPHOSARCOMA CELL LEUKEMIA. Am J Med. 1965 May;38:778–786. doi: 10.1016/0002-9343(65)90197-x. [DOI] [PubMed] [Google Scholar]
  21. Stein H., Petersen N., Gaedicke G., Lennert K., Landbeck G. Lymphoblastic lymphoma of convoluted or acid phosphatase type-a tumor of T precursor cells. Int J Cancer. 1976 Mar 15;17(3):292–295. doi: 10.1002/ijc.2910170303. [DOI] [PubMed] [Google Scholar]
  22. Winchester R. J., Kunkel H. G. The human Ia system. Adv Immunol. 1979;28:221–292. [PubMed] [Google Scholar]

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