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. 1982 Jan 1;155(1):179–189. doi: 10.1084/jem.155.1.179

Suppression of interstitial nephritis by auto-anti-idiotypic immunity

PMCID: PMC2186556  PMID: 6976412

Abstract

Rats immunized with renal tubular antigens were protected from the development of interstitial nephritis by pretreatment with tubular antigen-reactive T lymphoblasts. Protected animals developed anti- idiotypic antibodies against idiotypes primarily within the antigen- binding region of monoclonal antitubular basement membrane antibodies. These studies extend the concept of auto-anti-idiotypic regulation to autoimmune disease, and they also provide an experimental basis for further efforts to develop biologically relevant mechanisms for attenuating the expression of other kidney diseases.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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