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. 1983 May 1;157(5):1704–1709. doi: 10.1084/jem.157.5.1704

Mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80. Identification of resident macrophages in renal medullary and cortical interstitium and the juxtaglomerular complex

DA Hume, S Gordon
PMCID: PMC2186998  PMID: 6854206

Abstract

Macrophages have been identified in mouse kidney by immunohistochemical localization of the macrophage-specific antigen F4/80. They constitute the majority of the renal medullary interstitial cell population and are also found in contact with cortical distal and proximal tubules and Bowman's capsule. They are a physical component of the juxtaglomerular complex.

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Selected References

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  1. Austyn J. M., Gordon S. F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur J Immunol. 1981 Oct;11(10):805–815. doi: 10.1002/eji.1830111013. [DOI] [PubMed] [Google Scholar]
  2. Cotran R. S. Monocytes, proliferation, and glomerulonephritis. J Lab Clin Med. 1978 Dec;92(6):837–840. [PubMed] [Google Scholar]
  3. Dunn M. J., Staley R. S., Harrison M. Characterization of prostaglandin production in tissue culture of rat renal medullary cells. Prostaglandins. 1976 Jul;12(1):37–49. doi: 10.1016/s0090-6980(76)80005-6. [DOI] [PubMed] [Google Scholar]
  4. Franco-Saenz R., Suzuki S., Tan S. Y. Prostaglandins and renin production: a review. Prostaglandins. 1980 Dec;20(6):1131–1143. doi: 10.1016/0090-6980(80)90065-9. [DOI] [PubMed] [Google Scholar]
  5. Friedland J., Setton C., Silverstein E. Induction of angiotensin converting enzyme in human monocytes in culture. Biochem Biophys Res Commun. 1978 Aug 14;83(3):843–849. doi: 10.1016/0006-291x(78)91471-7. [DOI] [PubMed] [Google Scholar]
  6. Gelfand M. C., Frank M. M., Green I., Shin M. L. Binding sites for immune complexes containing IgG in the renal interstitium. Clin Immunol Immunopathol. 1979 May;13(1):19–29. doi: 10.1016/0090-1229(79)90016-3. [DOI] [PubMed] [Google Scholar]
  7. Hirsch S., Austyn J. M., Gordon S. Expression of the macrophage-specific antigen F4/80 during differentiation of mouse bone marrow cells in culture. J Exp Med. 1981 Sep 1;154(3):713–725. doi: 10.1084/jem.154.3.713. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Ho M. K., Springer T. A. Mac-1 antigen: quantitative expression in macrophage populations and tissues, and immunofluorescent localization in spleen. J Immunol. 1982 May;128(5):2281–2286. [PubMed] [Google Scholar]
  9. Hoffsten P. E., Swerdlin A., Bartell M., Hill C. L., Venverloh J., Brotherson K., Klahr S. Reticuloendothelial and mesangial function in murine immune complex glomerulonephritis. Kidney Int. 1979 Feb;15(2):144–159. doi: 10.1038/ki.1979.20. [DOI] [PubMed] [Google Scholar]
  10. Hsu S. M., Raine L., Fanger H. Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem. 1981 Apr;29(4):577–580. doi: 10.1177/29.4.6166661. [DOI] [PubMed] [Google Scholar]
  11. Hsueh W., Kuhn C., 3rd, Needleman P. Relationship of prostaglandin secretion by rabbit alveolar macrophages to phagocytosis and lysosomal enzyme release. Biochem J. 1979 Nov 15;184(2):345–354. doi: 10.1042/bj1840345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hunsicker L. G., Shearer T. P., Plattner S. B., Weisenburger D. The role of monocytes in serum sickness nephritis. J Exp Med. 1979 Sep 19;150(3):413–425. doi: 10.1084/jem.150.3.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Lee J. B. Prostaglandins and the renin-angiotensin axis. Clin Nephrol. 1980 Oct;14(4):159–163. [PubMed] [Google Scholar]
  14. Lee S., Vernier R. L. Immunoelectron microscopy of the glomerular mesangial uptake and transport of aggregated human albumin in the mouse. Lab Invest. 1980 Jan;42(1):44–58. [PubMed] [Google Scholar]
  15. Mason R. J., Stossel T. P., Vaughan M. Lipids of alveolar macrophages, polymorphonuclear leukocytes, and their phagocytic vesicles. J Clin Invest. 1972 Sep;51(9):2399–2407. doi: 10.1172/JCI107052. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Nasjletti A., Malik K. U. The renal kallikrein-kinin and prostaglandin systems interaction. Annu Rev Physiol. 1981;43:597–609. doi: 10.1146/annurev.ph.43.030181.003121. [DOI] [PubMed] [Google Scholar]
  17. Nussenzweig M. C., Steinman R. M., Unkeless J. C., Witmer M. D., Gutchinov B., Cohn Z. A. Studies of the cell surface of mouse dendritic cells and other leukocytes. J Exp Med. 1981 Jul 1;154(1):168–187. doi: 10.1084/jem.154.1.168. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rich I. N., Heit W., Kubanek B. Extrarenal erythropoietin production by macrophages. Blood. 1982 Oct;60(4):1007–1018. [PubMed] [Google Scholar]
  19. Ryan G. B., Coghlan J. P., Scoggins B. A. The granulated peripolar epithelial cell: a potential secretory component of the renal juxtaglomerular complex. Nature. 1979 Feb 22;277(5698):655–656. doi: 10.1038/277655a0. [DOI] [PubMed] [Google Scholar]
  20. Scott W. A., Zrike J. M., Hamill A. L., Kempe J., Cohn Z. A. Regulation of arachidonic acid metabolites in macrophages. J Exp Med. 1980 Aug 1;152(2):324–335. doi: 10.1084/jem.152.2.324. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Smith W. L., Bell T. G. Immunohistochemical localization of the prostaglandin-forming cyclooxygenase in renal cortex. Am J Physiol. 1978 Nov;235(5):F451–F457. doi: 10.1152/ajprenal.1978.235.5.F451. [DOI] [PubMed] [Google Scholar]
  22. Springer T., Galfré G., Secher D. S., Milstein C. Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol. 1979 Apr;9(4):301–306. doi: 10.1002/eji.1830090410. [DOI] [PubMed] [Google Scholar]
  23. Stokes J. B. Integrated actions of renal medullary prostaglandins in the control of water excretion. Am J Physiol. 1981 Jun;240(6):F471–F480. doi: 10.1152/ajprenal.1981.240.6.F471. [DOI] [PubMed] [Google Scholar]
  24. Striker G. E., Mannik M., Tung M. Y. Role of marrow-derived monocytes and mesangial cells in removal of immune complexes from renal glomeruli. J Exp Med. 1979 Jan 1;149(1):127–136. doi: 10.1084/jem.149.1.127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Weber P. C., Siess W. Interactions of renal prostaglandins with the renin-angiotensin system. Pharmacol Ther. 1981;15(2):321–337. doi: 10.1016/0163-7258(81)90048-6. [DOI] [PubMed] [Google Scholar]
  26. Wright F. S. Characteristics of feedback control of glomerular filtration rate. Fed Proc. 1981 Jan;40(1):87–92. [PubMed] [Google Scholar]
  27. Zins G. R. Renal prostaglandins. Am J Med. 1975 Jan;58(1):14–24. doi: 10.1016/0002-9343(75)90528-8. [DOI] [PubMed] [Google Scholar]
  28. Zusman R. M., Keiser H. R. Prostaglandin biosynthesis by rabbit renomedullary interstitial cells in tissue culture. Stimulation by angiotensin II, bradykinin, and arginine vasopressin. J Clin Invest. 1977 Jul;60(1):215–223. doi: 10.1172/JCI108758. [DOI] [PMC free article] [PubMed] [Google Scholar]

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