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. 1983 Jul 1;158(1):234–239. doi: 10.1084/jem.158.1.234

Lymphokine enhances oxygen-independent activity against intracellular pathogens

PMCID: PMC2187079  PMID: 6864162

Abstract

To determine if mechanisms other than the generation of toxic oxygen intermediates are active against intracellular pathogens, oxidatively deficient mouse L cells and monocyte-derived macrophages from patients with chronic granulomatous disease were stimulated with soluble lymphocyte products. Despite no enhancement in oxidative activity, these cells displayed effective microbistatic activity against both T. gondii and C. psittaci. These results suggest a potential role for nonoxidative mechanisms in the mononuclear phagocyte's activity against intracellular pathogens, and indicate that lymphokines can regulate both oxygen-dependent and oxygen-independent antimicrobial responses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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