Skip to main content
PMC home page
The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1984 Mar 1;159(3):655–665. doi: 10.1084/jem.159.3.655

Enhancement of the immune response to hepatitis B surface antigen. In vivo administration of antiidiotype induces anti-HBs that expresses a similar idiotype

PMCID: PMC2187246  PMID: 6607967

Abstract

BALB/c mice receiving antiidiotype antibodies before the injection of hepatitis B surface antigen (HBsAg) generated an enhanced anti-HBs response. Mice given antiidiotype antibodies in a soluble form induced predominantly IgM anti-HBs, whereas alum-precipitated antiidiotype produced primarily IgG anti-HBs. Injection of antiidiotype antibodies alone induced anti-HBs that inhibited a common interspecies anti-HBs idiotype-antiidiotype reaction and recognized the group-specific determinant of HBsAg. These data support the view that antiidiotype antibodies may modulate the immune response to an infectious viral agent.

Full Text

The Full Text of this article is available as a PDF (653.1 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Almeida J. D. Individual morphological variations seen in Australia antigen positive sera. Am J Dis Child. 1972 Apr;123(4):303–309. doi: 10.1001/archpedi.1972.02110100035013. [DOI] [PubMed] [Google Scholar]
  2. Bancroft W. H., Mundon F. K., Russell P. K. Detection of additional antigenic determinants of hepatitis B antigen. J Immunol. 1972 Oct;109(4):842–848. [PubMed] [Google Scholar]
  3. Bluestone J. A., Sharrow S. O., Epstein S. L., Ozato K., Sachs D. H. Induction of anti-H-2 antibodies without alloantigen exposure by in vivo administration of anti-idiotype. Nature. 1981 May 21;291(5812):233–235. doi: 10.1038/291233a0. [DOI] [PubMed] [Google Scholar]
  4. Dreesman G. R., Hollinger F. B., McCombs R. M., Melnick J. L. Production of potent anti-Australia antigen sera of high specificity and sensitivity in goats. Infect Immun. 1972 Feb;5(2):213–221. doi: 10.1128/iai.5.2.213-221.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Eichmann K. Idiotype suppression. I. Influence of the dose and of the effector functions of anti-idiotypic antibody on the production of an idiotype. Eur J Immunol. 1974 Apr;4(4):296–302. doi: 10.1002/eji.1830040413. [DOI] [PubMed] [Google Scholar]
  6. Epstein S. L., Masakowski V. R., Sharrow S. O., Bluestone J. A., Ozato K., Sachs D. H. Idiotypes of anti-Ia antibodies. II. Effects of in vivo treatment with xenogeneic anti-idiotype. J Immunol. 1982 Oct;129(4):1545–1552. [PubMed] [Google Scholar]
  7. Frischknecht H., Binz H., Wigzell H. Induction of specific transplantation immune reactions using anti-idiotypic antibodies. J Exp Med. 1978 Feb 1;147(2):500–514. doi: 10.1084/jem.147.2.500. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. GREENWOOD F. C., HUNTER W. M., GLOVER J. S. THE PREPARATION OF I-131-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY. Biochem J. 1963 Oct;89:114–123. doi: 10.1042/bj0890114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gerety R. J., Tabor E., Purcell R. H., Tyeryar F. J. Summary of an international workshop on hepatitis B vaccines. J Infect Dis. 1979 Oct;140(4):642–648. doi: 10.1093/infdis/140.4.642. [DOI] [PubMed] [Google Scholar]
  10. Ionescu-Matiu I., Kennedy R. C., Sparrow J. T., Culwell A. R., Sanchez Y., Melnick J. L., Dreesman G. R. Epitopes associated with a synthetic hepatitis B surface antigen peptide. J Immunol. 1983 Apr;130(4):1947–1952. [PubMed] [Google Scholar]
  11. Ionescu-Matiu I., Sanchez Y., Fields H. A., Dreesman G. R. Development of sensitive immunoassays for detection of antibodies against hepatitis B surface antigen. J Virol Methods. 1983 Jan;6(1):41–52. doi: 10.1016/0166-0934(83)90066-6. [DOI] [PubMed] [Google Scholar]
  12. Jerne N. K. Towards a network theory of the immune system. Ann Immunol (Paris) 1974 Jan;125C(1-2):373–389. [PubMed] [Google Scholar]
  13. Kennedy R. C., Adler-Storthz K., Henkel R. D., Dreesman G. R. Characteristics of a shared idiotype by two IgM anti-herpes simplex virus monoclonal antibodies that recognize different determinants. J Immunol. 1983 Apr;130(4):1943–1946. [PubMed] [Google Scholar]
  14. Kennedy R. C., Adler-Storthz K., Henkel R. D., Sanchez Y., Melnick J. L., Dreesman G. R. Immune response to hepatitis B surface antigen: enhancement by prior injection of antibodies to the idiotype. Science. 1983 Aug 26;221(4613):853–855. doi: 10.1126/science.6603657. [DOI] [PubMed] [Google Scholar]
  15. Kennedy R. C., Dreesman G. R. Common idiotypic determinant associated with human antibodies to hepatitis B surface antigen. J Immunol. 1983 Jan;130(1):385–389. [PubMed] [Google Scholar]
  16. Kennedy R. C., Dreesman G. R. Production and characterization of anti-idiotype reagents for the analysis of viral antigen systems. J Virol Methods. 1983 Aug;7(2):103–115. doi: 10.1016/0166-0934(83)90096-4. [DOI] [PubMed] [Google Scholar]
  17. Kennedy R. C., Dreesman G. R., Sparrow J. T., Culwell A. R., Sanchez Y., Ionescu-Matiu I., Hollinger F. B., Melnick J. L. Inhibition of a common human anti-hepatitis B surface antigen idiotype by a cyclic synthetic peptide. J Virol. 1983 May;46(2):653–655. doi: 10.1128/jvi.46.2.653-655.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Kennedy R. C., Ionescu-Matiu I., Sanchez Y., Dreesman G. R. Detection of interspecies idiotypic cross-reactions associated with antibodies to hepatitis B surface antigen. Eur J Immunol. 1983 Mar;13(3):232–235. doi: 10.1002/eji.1830130310. [DOI] [PubMed] [Google Scholar]
  19. Kennedy R. C., Sanchez Y., Ionescu-Matiu I., Melnick J. L., Dreesman G. R. A common human anti-hepatitis B surface antigen idiotype is associated with the group a conformation-dependent antigenic determinant. Virology. 1982 Oct 15;122(1):219–221. doi: 10.1016/0042-6822(82)90394-4. [DOI] [PubMed] [Google Scholar]
  20. Kunkel H. G., Mannik M., Williams R. C. Individual Antigenic Specificity of Isolated Antibodies. Science. 1963 Jun 14;140(3572):1218–1219. doi: 10.1126/science.140.3572.1218. [DOI] [PubMed] [Google Scholar]
  21. Le Bouvier G. L. The heterogeneity of Australia antigen. J Infect Dis. 1971 Jun;123(6):671–675. doi: 10.1093/infdis/123.6.671. [DOI] [PubMed] [Google Scholar]
  22. Nisonoff A., Lamoyi E. Implications of the presence of an internal image of the antigen in anti-idiotypic antibodies: possible application to vaccine production. Clin Immunol Immunopathol. 1981 Dec;21(3):397–406. doi: 10.1016/0090-1229(81)90228-2. [DOI] [PubMed] [Google Scholar]
  23. Pawlak L. L., Hart D. A., Nisonoff A. Requirements for prolonged suppression of an idiotypic specificity in adult mice. J Exp Med. 1973 Jun 1;137(6):1442–1458. doi: 10.1084/jem.137.6.1442. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Robinson W. S. The genome of hepatitis B virus. Annu Rev Microbiol. 1977;31:357–377. doi: 10.1146/annurev.mi.31.100177.002041. [DOI] [PubMed] [Google Scholar]
  25. Rodkey L. S. Autoregulation of immune responses via idiotype network interactions. Microbiol Rev. 1980 Dec;44(4):631–659. doi: 10.1128/mr.44.4.631-659.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Sacks D. L., Esser K. M., Sher A. Immunization of mice against African trypanosomiasis using anti-idiotypic antibodies. J Exp Med. 1982 Apr 1;155(4):1108–1119. doi: 10.1084/jem.155.4.1108. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Sacks D. L., Kelsoe G. H., Sachs D. H. Induction of immune responses with anti-idiotypic antibodies: implications for the induction of protective immunity. Springer Semin Immunopathol. 1983;6(1):79–97. doi: 10.1007/BF01857368. [DOI] [PubMed] [Google Scholar]
  28. Sanchez Y., Ionescu-Matiu I. I., Sparrow J. T., Melnick J. L., Dreesman G. R. Immunogenicity of conjugates and micelles of synthetic hepatitis B surface antigen peptides. Intervirology. 1982;18(4):209–213. doi: 10.1159/000149327. [DOI] [PubMed] [Google Scholar]
  29. Sanchez Y., Ionescu-Matiu I., Dreesman G. R., Kramp W., Six H. R., Hollinger F. B., Melnick J. L. Humoral and cellular immunity to hepatitis B virus-derived antigens: comparative activity of Freund complete adjuvant alum, and liposomes. Infect Immun. 1980 Dec;30(3):728–733. doi: 10.1128/iai.30.3.728-733.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Szmuness W., Stevens C. E., Harley E. J., Zang E. A., Oleszko W. R., William D. C., Sadovsky R., Morrison J. M., Kellner A. Hepatitis B vaccine: demonstration of efficacy in a controlled clinical trial in a high-risk population in the United States. N Engl J Med. 1980 Oct 9;303(15):833–841. doi: 10.1056/NEJM198010093031501. [DOI] [PubMed] [Google Scholar]
  31. Takemori T., Tesch H., Reth M., Rajewsky K. The immune response against anti-idiotope antibodies. I. Induction of idiotope-bearing antibodies and analysis of the idiotope repertoire. Eur J Immunol. 1982 Dec;12(12):1040–1046. doi: 10.1002/eji.1830121210. [DOI] [PubMed] [Google Scholar]
  32. Urbain J., Wuilmart C., Cazenave P. A. Idiotypic regulation in immune networks. Contemp Top Mol Immunol. 1981;8:113–148. doi: 10.1007/978-1-4684-3917-5_4. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES