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. 1985 May 1;161(5):1189–1195. doi: 10.1084/jem.161.5.1189

Human genes for three complement components that regulate the activation of C3 are tightly linked

PMCID: PMC2187593  PMID: 3157763

Abstract

A new cluster of complement component genes, including C4BP, C3bR, and FH, is described. Family segregation data indicate that FH is linked to the genes for C4-bp and C4bR, previously reported to be linked and to maintain linkage disequilibrium. This cluster is not linked to the major histocompatibility complex, which contains the genes for the complement components, C4, C2, and factor B, or to the C3 locus. These data further suggest that the organization of genes for functionally related proteins in clusters may be a rule for the complement system.

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Selected References

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