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. 1985 Sep 1;162(3):1087–1092. doi: 10.1084/jem.162.3.1087

Restriction fragment length polymorphism of the gene encoding the alpha chain of the human T cell receptor

PMCID: PMC2187817  PMID: 2993469

Abstract

Two allelic forms of the T cell antigen receptor alpha chain gene were discerned by restriction fragment length polymorphism (RFLP) employing the T cell antigen receptor alpha chain probe pGA5, and the restriction enzyme Bgl II. Analysis revealed that the polymorphic fragments are detected by a probe specific for the constant region exon of the T cell antigen receptor alpha chain gene. Furthermore, the polymorphic fragments were shown to segregate within families. The two allelic forms yield two homozygous states, 3.2/3.2 and 2.9/2.9, at a frequency of 76.5 and 2.9%, respectively, within the normal population. The heterozygous state was observed in 20.6% of the population. The discovery of allelic forms of both the alpha and beta chains of the T cell antigen receptor genes may provide a unique opportunity to study heritable markers of T cell function in several human diseases.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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