Abstract
We show that downregulation of arachidonic acid (20:4) metabolism which occurs following i.p. injection of C. parvum can occur in a single, localized macrophage population, and is therefore unlikely to be mediated solely by a systemic factor.
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- COHN Z. A., BENSON B. THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES. MORPHOLOGY, CYTOCHEMISTRY, AND BIOCHEMISTRY. J Exp Med. 1965 Jan 1;121:153–170. doi: 10.1084/jem.121.1.153. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Humes J. L., Burger S., Galavage M., Kuehl F. A., Jr, Wightman P. D., Dahlgren M. E., Davies P., Bonney R. J. The diminished production of arachidonic acid oxygenation products by elicited mouse peritoneal macrophages: possible mechanisms. J Immunol. 1980 May;124(5):2110–2116. [PubMed] [Google Scholar]
- LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
- Nathan C. F., Murray H. W., Wiebe M. E., Rubin B. Y. Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity. J Exp Med. 1983 Sep 1;158(3):670–689. doi: 10.1084/jem.158.3.670. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pawlowski N. A., Scott W. A., Andreach M., Cohn Z. A. Uptake and metabolism of monohydroxy-eicosatetraenoic acids by macrophages. J Exp Med. 1982 Jun 1;155(6):1653–1664. doi: 10.1084/jem.155.6.1653. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rouzer C. A., Scott W. A., Griffith O. W., Hamill A. L., Cohn Z. A. Depletion of glutathione selectively inhibits synthesis of leukotriene C by macrophages. Proc Natl Acad Sci U S A. 1981 Apr;78(4):2532–2536. doi: 10.1073/pnas.78.4.2532. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rouzer C. A., Scott W. A., Hamill A. L., Cohn Z. A. Dynamics of leukotriene C production by macrophages. J Exp Med. 1980 Nov 1;152(5):1236–1247. doi: 10.1084/jem.152.5.1236. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sadler T. E., Cramp W. A., Castro J. E. Radiolabelling of Corynebacterium parvum and its distribution in mice. Br J Cancer. 1977 Mar;35(3):357–368. doi: 10.1038/bjc.1977.50. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Scott W. A., Pawlowski N. A., Murray H. W., Andreach M., Zrike J., Cohn Z. A. Regulation of arachidonic acid metabolism by macrophage activation. J Exp Med. 1982 Apr 1;155(4):1148–1160. doi: 10.1084/jem.155.4.1148. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Scott W. A., Zrike J. M., Hamill A. L., Kempe J., Cohn Z. A. Regulation of arachidonic acid metabolites in macrophages. J Exp Med. 1980 Aug 1;152(2):324–335. doi: 10.1084/jem.152.2.324. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tripp C. S., Leahy K. M., Needleman P. Thromboxane synthase is preferentially conserved in activated mouse peritoneal macrophages. J Clin Invest. 1985 Aug;76(2):898–901. doi: 10.1172/JCI112051. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zlotnik A., Vatter A., Hayes R. L., Blumenthal E., Crowle A. J. Mouse pleural macrophages: characterization and comparison with mouse alveolar and peritoneal macrophages. J Reticuloendothel Soc. 1982 Mar;31(3):207–220. [PubMed] [Google Scholar]