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. 1986 Jun 1;163(6):1595–1600. doi: 10.1084/jem.163.6.1595

Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor

PMCID: PMC2188126  PMID: 3086483

Abstract

Human endothelial cells activated with IL-1 express a surface membrane- oriented procoagulant generating system characterized by increased tissue factor synthesis and decreased thrombomodulin activity. We now report that IL-1 also stimulates endothelial cell synthesis of plasminogen activator inhibitor. This array of IL-1-induced activities shifts the balance at the endothelial cell surface to a prothrombotic influence and may reflect an early response of the blood vessel wall to injury.

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Selected References

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