Abstract
We have shown in a murine model system for cytomegalovirus (CMV) disease in the immunocompromised host that in vivo application of recombinant human IL-2 (rhIL-2) can enhance the antiviral effect of a limited number of CD8+T lymphocytes, not only in prophylaxis, but also in therapy, when virus has already colonized host tissues. The observed net effect of IL-2 was consistent with the assumption of daily effector population doublings. The prospects for IL-2-supported immunotherapy of established CMV infection depend upon the tissues involved in disease. It appears that the prospects for controlling established CMV adrenalitis are less promising than for a therapy of interstitial CMV pneumonia.
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Selected References
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- Brody A. R., Craighead J. E. Pathogenesis of pulmonary cytomegalovirus infection in immunosuppressed mice. J Infect Dis. 1974 Jun;129(6):677–689. doi: 10.1093/infdis/129.6.677. [DOI] [PubMed] [Google Scholar]
- Bukowski J. F., Woda B. A., Welsh R. M. Pathogenesis of murine cytomegalovirus infection in natural killer cell-depleted mice. J Virol. 1984 Oct;52(1):119–128. doi: 10.1128/jvi.52.1.119-128.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cheever M. A., Thompson D. B., Klarnet J. P., Greenberg P. D. Antigen-driven long term-cultured T cells proliferate in vivo, distribute widely, mediate specific tumor therapy, and persist long-term as functional memory T cells. J Exp Med. 1986 May 1;163(5):1100–1112. doi: 10.1084/jem.163.5.1100. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cheever M. A., Thompson J. A., Peace D. J., Greenberg P. D. Potential uses of interleukin 2 in cancer therapy. Immunobiology. 1986 Sep;172(3-5):365–382. doi: 10.1016/S0171-2985(86)80118-8. [DOI] [PubMed] [Google Scholar]
- Ettinghausen S. E., Rosenberg S. A. The adoptive immunotherapy of cancer using lymphokine activated killer cells and recombinant interleukin-2. Springer Semin Immunopathol. 1986;9(1):51–71. [PubMed] [Google Scholar]
- Hanshaw J. B. Congenital cytomegalovirus infection: a fifteen year perspective. J Infect Dis. 1971 May;123(5):555–561. doi: 10.1093/infdis/123.5.555. [DOI] [PubMed] [Google Scholar]
- Lotze M. T., Rosenberg S. A. Results of clinical trials with the administration of interleukin 2 and adoptive immunotherapy with activated cells in patients with cancer. Immunobiology. 1986 Sep;172(3-5):420–437. doi: 10.1016/S0171-2985(86)80122-X. [DOI] [PubMed] [Google Scholar]
- Meyers J. D., Flournoy N., Thomas E. D. Cytomegalovirus infection and specific cell-mediated immunity after marrow transplant. J Infect Dis. 1980 Dec;142(6):816–824. doi: 10.1093/infdis/142.6.816. [DOI] [PubMed] [Google Scholar]
- Niedt G. W., Schinella R. A. Acquired immunodeficiency syndrome. Clinicopathologic study of 56 autopsies. Arch Pathol Lab Med. 1985 Aug;109(8):727–734. [PubMed] [Google Scholar]
- Reddehase M. J., Koszinowski U. H. Significance of herpesvirus immediate early gene expression in cellular immunity to cytomegalovirus infection. Nature. 1984 Nov 22;312(5992):369–371. doi: 10.1038/312369a0. [DOI] [PubMed] [Google Scholar]
- Reddehase M. J., Weiland F., Münch K., Jonjic S., Lüske A., Koszinowski U. H. Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs. J Virol. 1985 Aug;55(2):264–273. doi: 10.1128/jvi.55.2.264-273.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rook A. H., Masur H., Lane H. C., Frederick W., Kasahara T., Macher A. M., Djeu J. Y., Manischewitz J. F., Jackson L., Fauci A. S. Interleukin-2 enhances the depressed natural killer and cytomegalovirus-specific cytotoxic activities of lymphocytes from patients with the acquired immune deficiency syndrome. J Clin Invest. 1983 Jul;72(1):398–403. doi: 10.1172/JCI110981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shanley J. D., Pesanti E. L. Murine cytomegalovirus adrenalitis in athymic nude mice. Arch Virol. 1986;88(1-2):27–35. doi: 10.1007/BF01310887. [DOI] [PubMed] [Google Scholar]
- Tapper M. L., Rotterdam H. Z., Lerner C. W., Al'Khafaji K., Seitzman P. A. Adrenal necrosis in the acquired immunodeficiency syndrome. Ann Intern Med. 1984 Feb;100(2):239–241. doi: 10.7326/0003-4819-100-2-239. [DOI] [PubMed] [Google Scholar]