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. 1990 Aug 1;172(2):531–536. doi: 10.1084/jem.172.2.531

Heavy-chain class switch does not terminate somatic mutation

PMCID: PMC2188341  PMID: 2115570

Abstract

We studied the H-chain class switch rearrangement in four groups of clonally related B cell hybridomas, to test the hypothesis that class switch terminates somatic mutation in a B cell. Using switch region- specific probes in Southern blot analysis individual mu-gamma switch rearrangement events can be distinguished. We show that clonally related IgG-producing hybridomas that differ by mutations often share a common switch rearrangement. This indicates that class switch in these cells did not terminate somatic mutation.

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Selected References

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