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. 1986 Sep 1;164(3):944–949. doi: 10.1084/jem.164.3.944

Induction of the c-myc protooncogene after antigen binding to hapten- specific B cells

PMCID: PMC2188380  PMID: 3489063

Abstract

The stimulation of hapten-specific B cell populations with the thymus- dependent antigen, TNP-KLH, was found to induce elevated levels of c- myc mRNA by 2 h. A similar treatment with carrier protein alone did not elevate c-myc mRNA above the level seen in the nonstimulated, resting B cells. These results indicate that antigen binding to the sIg receptor, in the absence of Th cell involvement, directly signals the antigen- binding cell and implicates the active participation of sIg during the process of antigen-mediated B cell activation.

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Selected References

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