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. 1986 Sep 1;164(3):962–967. doi: 10.1084/jem.164.3.962

Self-sparing of long-term in vitro-cloned or uncloned cytotoxic T lymphocytes

PMCID: PMC2188387  PMID: 3489065

Abstract

At least some long-term in vitro-cultured cytotoxic T cell clones and uncloned cell populations are able, in the presence of Con A, to lyse other cells, to be lysed by other cells, but not to lyse themselves. This as-yet-unexplained result may have implications as to the mechanism of T cell-mediated cytotoxicity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Albert F., Buferne M., Boyer C., Schmitt-Verhulst A. M. Interactions between MHC-encoded products and cloned T-cells. I. Fine specificity of induction of proliferation and lysis. Immunogenetics. 1982;16(6):533–549. doi: 10.1007/BF00372022. [DOI] [PubMed] [Google Scholar]
  2. Haas W., Kisielow P. Cytolytic T cell hybridomas. I. Interleukin 2-independent noncytolytic variants. Eur J Immunol. 1985 Aug;15(8):751–755. doi: 10.1002/eji.1830150802. [DOI] [PubMed] [Google Scholar]
  3. Kuppers R. C., Henney C. S. Studies on the mechanism of lymphocyte-mediated cytolysis. IX. Relationships between antigen recognition and lytic expression in killer T cells. J Immunol. 1977 Jan;118(1):71–76. [PubMed] [Google Scholar]
  4. Lanzavecchia A. Is the T-cell receptor involved in T-cell killing? 1986 Feb 27-Mar 5Nature. 319(6056):778–780. doi: 10.1038/319778a0. [DOI] [PubMed] [Google Scholar]
  5. Pierres A., Schmitt-Verhulst A. M., Buferne M., Golstein P., Pierres M. Characterization of an Lyt-1+ cytolytic T-cell clone specific for a polymorphic domain of the I-Ak molecule. Scand J Immunol. 1982 Jun;15(6):619–625. doi: 10.1111/j.1365-3083.1982.tb00691.x. [DOI] [PubMed] [Google Scholar]

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