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. 1990 Sep 1;172(3):989–992. doi: 10.1084/jem.172.3.989

Protein kinase regulates tumor necrosis factor mRNA stability in virus- stimulated astrocytes

PMCID: PMC2188550  PMID: 2388040

Abstract

Infection of astrocytes with Newcastle disease virus stimulated the production of 1,2-diacylglycerol, and resulted in the kinase-dependent expression of mRNAs encoding tumor necrosis factor (TNF), interferon alpha and beta, and interleukin 6. The half-life of TNF mRNA was significantly decreased in the presence of protein kinase inhibitors H- 7 and staurosporine, but not in the presence of HA1004. In contrast to the decay of TNF mRNA, the half-lives of other cytokine mRNAs were only minimally affected by the kinase inhibitors. These data indicated that the stability of TNF mRNA was regulated through a novel, kinase- dependent pathway.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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