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. 1987 Apr 1;165(4):1230–1235. doi: 10.1084/jem.165.4.1230

The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain

PMCID: PMC2188581  PMID: 3104529

Abstract

The expression of the CD4 antigen in normal human brain was investigated in parallel by immunohistochemical and Northern blot analyses. With anti-CD4 antibodies detecting different epitopes of the molecule, CD4+ neurons were defined in the cerebellum, thalamus, and pons. CD4+ glial cells were identified in the thalamus and pons. CD4- specific mRNA was detected in all three subareas and in the hippocampus, while other subareas were negative. The CD4+ cells were negative with anti-T cell antibodies (anti-CD2 and anti-CD8), as well as with antimonocyte antibodies (M-M 522 and M-M 42).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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