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The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1990 Oct 1;172(4):1271–1274. doi: 10.1084/jem.172.4.1271

Activation of platelets by eosinophil granule proteins

PMCID: PMC2188607  PMID: 2212954

Abstract

Two of the four principal cationic proteins of the eosinophil granule, major basic protein (MBP) and eosinophil peroxidase (EPO), were shown to be platelet agonists. Both MBP and EPO evoked a dose-dependent nonlytic secretion of platelet 5-hydroxytryptamine in unstirred platelet suspensions even in the presence of 10 microM indomethacin. MBP also evoked secretion of platelet alpha granule and lysosome components. Secretion by MBP and EPO was inhibited by 1 microM PGE1, but the nature of the inhibition differed from that observed with thrombin. Thus, MBP and EPO can be classified as strong platelet agonists with a distinct mechanism of activation.

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Selected References

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