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. 1988 Dec 1;168(6):2361–2366. doi: 10.1084/jem.168.6.2361

Distinct patterns of heavy chain variable region subgroup use by human monoclonal autoantibodies of different specificity

PMCID: PMC2189130  PMID: 3143801

Abstract

Using a panel of antibodies specific for H and L chain variable region subgroups, a panel of human monoclonal cold agglutinin (CA) and rheumatoid factor (RF) autoantibodies were analyzed. The vast majority of the two types of autoantibodies utilized VkIII L chains, many of which probably derive from the Humkv325 gene. However, while most RFs (77%) utilized VHI H chains, all the CAs used VHII subgroup H chains. These results are consistent with a model of autoantibody generation, wherein binding specificity is H chain defined in a set of antibodies that use a multipotential L chain.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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