Abstract
Specific suppressor cells have been demonstrated in mice tolerant to the thymus-dependent antigen HGG. Transfer of normal thymocytes, normal spleen cells, or immune spleen cells into these tolerant mice did not restore immunocompetence to HGG. Furthermore, the transfer of tolerant spleen cells into normal recipients abrogated the response of these recipients to subsequent challenge with immunogenic HGG. Spleen cells removed from mice 5, 8, or 11 wk after the induction of tolerance specifically suppressed the response of normal spleen cells in an adoptive cell transfer system. The extent of suppression appears to be dependent upon how long after the induction of tolerance the cells were removed from the tolerant donors and how soon after transfer the recipients were challenged.
Full Text
The Full Text of this article is available as a PDF (713.1 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Basten A., Miller J. F., Sprent J., Cheers C. Cell-to-cell interaction in the immune response. X. T-cell-dependent suppression in tolerant mice. J Exp Med. 1974 Jul 1;140(1):199–217. doi: 10.1084/jem.140.1.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Benjamin D. C. The termination of immunologic unresponsiveness to BSA in rabbits by transfer of normal sibling thymocytes. J Immunol. 1974 Nov;113(5):1589–1592. [PubMed] [Google Scholar]
- Benjamin D. C., Weigle W. O. Frequency of single spleen cells from hyperimmune rabbits producing antibody of two different specificities. J Immunol. 1970 Sep;105(3):537–540. [PubMed] [Google Scholar]
- Benjamin D. C., Weigle W. O. The termination of immunological unresponsiveness to bovine serum albumin in rabbits. I. Quantitative and qualitative response to cross-reacting albumins. J Exp Med. 1970 Jul 1;132(1):66–76. doi: 10.1084/jem.132.1.66. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chiller J. M., Habicht G. S., Weigle W. O. Cellular sites of immunologic unresponsiveness. Proc Natl Acad Sci U S A. 1970 Mar;65(3):551–556. doi: 10.1073/pnas.65.3.551. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chiller J. M., Habicht G. S., Weigle W. O. Kinetic differences in unresponsiveness of thymus and bone marrow cells. Science. 1971 Feb 26;171(3973):813–815. doi: 10.1126/science.171.3973.813. [DOI] [PubMed] [Google Scholar]
- Chiller J. M., Weigle W. O. Cellular events during induction of immunologic unresponsiveness in adult mice. J Immunol. 1971 Jun;106(6):1647–1653. [PubMed] [Google Scholar]
- Chiller J. M., Weigle W. O. Termination of tolerance to human gamma globulin in mice by antigen and bacterial lipopolysaccharide (endotoxin). J Exp Med. 1973 Mar 1;137(3):740–750. doi: 10.1084/jem.137.3.740. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DRESSER D. W. Specific inhibition of antibody production. II. Paralysis induced in adult mice by small quantities of protein antigen. Immunology. 1962 May;5:378–388. [PMC free article] [PubMed] [Google Scholar]
- Golub E. S., Mishell R. I., Weigle W. O., Dutton R. W. A modification of the hemolytic plaque assay for use with protein antigens. J Immunol. 1968 Jan;100(1):133–137. [PubMed] [Google Scholar]
- Golub E. S., Weigle W. O. Studies on the induction of immunologic unresponsiveness. I. Effects of endotoxin and phytochemagglutinin. J Immunol. 1967 Jun;98(6):1241–1247. [PubMed] [Google Scholar]
- Herzenberg L. A., Chan E. L., Ravitch M. M., Riblet R. J., Herzenberg L. A. Active suppression of immunoglobulin allotype synthesis. 3. Identification of T cells as responsible for suppression by cells from spleen, thymus, lymph node, and bone marrow. J Exp Med. 1973 Jun 1;137(6):1311–1324. doi: 10.1084/jem.137.6.1311. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MCPHERSON C. W. REDUCTION OF PSEUDOMONAS AERUGINOSA AND COLIFORM BACTERIA IN MOUSE DRINKING WATER FOLLOWING TREATMENT WITH HYDROCHLORIC ACID OR CHLORINE. Lab Anim Care. 1963 Oct;13:737–744. [PubMed] [Google Scholar]
- McConahey P. J., Dixon F. J. A method of trace iodination of proteins for immunologic studies. Int Arch Allergy Appl Immunol. 1966;29(2):185–189. doi: 10.1159/000229699. [DOI] [PubMed] [Google Scholar]
- McCullagh P. J. The abrogation of sheep erythrocyte tolerance in rats by means of the transfer of allogeneic lymphocytes. J Exp Med. 1970 Nov;132(5):916–925. doi: 10.1084/jem.132.5.916. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McCullagh P. J. The immunological capacity of lymphocytes from normal donors after their transfer to rats tolerant of sheep erythrocytes. Aust J Exp Biol Med Sci. 1970 Aug;48(4):369–379. doi: 10.1038/icb.1970.39. [DOI] [PubMed] [Google Scholar]
- McCullagh P. J. The transfer of immunological competence to rats tolerant of sheep erythrocytes with lymphocytes from normal rats. Aust J Exp Biol Med Sci. 1970 Aug;48(4):351–367. doi: 10.1038/icb.1970.38. [DOI] [PubMed] [Google Scholar]
- Miller J. F., Mitchell G. F. Cell to cell interaction in the immune response. V. Target cells for tolerance induction. J Exp Med. 1970 Apr 1;131(4):675–699. doi: 10.1084/jem.131.4.675. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ruben T. J., Chiller J. M., Weigle W. O. The cellular basis of cross-tolerance. J Immunol. 1973 Sep;111(3):805–810. [PubMed] [Google Scholar]
- Scibienski R. J., Harris L. M., Fong S., Benjamini E. Active and inactive states of immunologic unresponsiveness. J Immunol. 1974 Jul;113(1):45–50. [PubMed] [Google Scholar]
- Tada T., Takemori T. Selective roles of thymus-derived lymphocytes in the antibody response. I. Differential suppressive effect of carrier-primed T cells on hapten-specific IgM and IgG antibody responses. J Exp Med. 1974 Jul 1;140(1):239–252. doi: 10.1084/jem.140.1.239. [DOI] [PMC free article] [PubMed] [Google Scholar]