Abstract
Six cases of acute lymphoblastic leukemia were studied by a variety of T- and B-lymphocyte surface markers. Two appeared to represent T-cell leukemias with the lymphoblasts forming sheep erythrocyte rosettes. The other four lacked all the usual membrane markers. However, indirect immunofluorescence with alloantisera detected the presence of the Ia- related HL-B antigens on the cells of the latter four cases; these antigens were absent in the first two cases. The primary association of the HL-B antigens with B cells raises the possibility that the positive group of cases are of B-cell lineage.
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Selected References
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- Bentwich Z., Kunkel H. G. Specific properties of human B and T lymphocytes and alterations in disease. Transplant Rev. 1973;16:29–50. doi: 10.1111/j.1600-065x.1973.tb00116.x. [DOI] [PubMed] [Google Scholar]
- Davey F. R., Gottlieb A. J. Lymphocyte surface markers in acute lymphocytic leukemia. Am J Clin Pathol. 1974 Dec;62(6):818–822. doi: 10.1093/ajcp/62.6.818. [DOI] [PubMed] [Google Scholar]
- Fu S. M., Winchester R. J., Kunkel H. G. Occurrence of surface IgM, IgD, and free light chains of human lymphocytes. J Exp Med. 1974 Feb 1;139(2):451–456. doi: 10.1084/jem.139.2.451. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fu S. M., Winchester R. J., Kunkel H. G. Similar idiotypic specificity for the membrane IgD and IgM of human B lymphocytes. J Immunol. 1975 Jan;114(1 Pt 1):250–252. [PubMed] [Google Scholar]
- Fu S. M., Winchester R. J., Rai K. R., Kunkel H. G. Hairy cell leukemia: proliferation of a cell with phagocytic and B-lymphocyte properties. Scand J Immunol. 1974;3(6):847–851. doi: 10.1111/j.1365-3083.1974.tb01322.x. [DOI] [PubMed] [Google Scholar]
- Greaves M. F., Brown G., Rapson N. T., Lister T. A. Antisera to acute lymphoblastic leukemia cells. Clin Immunol Immunopathol. 1975 May;4(1):67–84. doi: 10.1016/0090-1229(75)90041-0. [DOI] [PubMed] [Google Scholar]
- Mann D. L., Abelson L., Harris S., Amos D. B. Detection of antigens specific for B-lymphoid cultured cell lines with human alloantisera. J Exp Med. 1975 Jul 1;142(1):84–89. doi: 10.1084/jem.142.1.84. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Winchester R. J., Fu S. M., Hoffman T., Kunkel H. G. IgG on lymphocyte surfaces; technical problems and the significance of a third cell population. J Immunol. 1975 Apr;114(4):1210–1212. [PubMed] [Google Scholar]
- Winchester R. J., Wernet P., Kunkel H. G., Dupont B., Jersild C., Fu S. M. Recognition by pregnancy serums of non-HL-A alloantigens selectively expressed on B lymphocytes. J Exp Med. 1975 Apr 1;141(4):924–929. [PMC free article] [PubMed] [Google Scholar]