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. 1976 Jan 1;143(1):85–99. doi: 10.1084/jem.143.1.85

Studies on the role of the host immune response in recovery from Friend virus leukemia. II. Cell-mediated immunity

PMCID: PMC2190102  PMID: 1081583

Abstract

Congenic mouse strains differing only at genes within the H-2 complex were found to have virus-specific cytotoxic effector cells in their spleens during or after recovery from Friend leukemia virus-induced splenomegaly. These effector cells were theta-positive T lymphocytes which functioned in vitro without help or inhibition by B lymphocytes or glass-adherent cells. The antigenic specificities recognized by the effector cells were viral-induced cellular antigens apparently different from those identified by serological techniques.

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Selected References

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  1. Ariyan S., Gershon R. K. Augmentation of the adoptive transfer of specific tumor immunity by non-specifically immunized macrophages. J Natl Cancer Inst. 1973 Oct;51(4):1145–1148. doi: 10.1093/jnci/51.4.1145. [DOI] [PubMed] [Google Scholar]
  2. BILLINGHAM R. E., BRENT L., MEDAWAR P. B. Quantitative studies on tissue transplantation immunity. II. The origin, strength and duration of actively and adoptively acquired immunity. Proc R Soc Lond B Biol Sci. 1954 Dec 15;143(910):58–80. doi: 10.1098/rspb.1954.0054. [DOI] [PubMed] [Google Scholar]
  3. Berenson J. R., Einstein A. B., Jr, Fefer A. Syngeneic adoptive immunotherapy and chemoimmunotherapy of a Friend leukemia: requirement for T cells. J Immunol. 1975 Jul;115(1):234–238. [PubMed] [Google Scholar]
  4. Brunner K. T., Mauel J., Cerottini J. C., Chapuis B. Quantitative assay of the lytic action of immune lymphoid cells on 51-Cr-labelled allogeneic target cells in vitro; inhibition by isoantibody and by drugs. Immunology. 1968 Feb;14(2):181–196. [PMC free article] [PubMed] [Google Scholar]
  5. Canty T. G., Wunderlich J. R. Quantitative in vitro assay of cytotoxic cellular immunity. J Natl Cancer Inst. 1970 Oct;45(4):761–772. [PubMed] [Google Scholar]
  6. Cerottini J. C., Brunner K. T. Cell-mediated cytotoxicity, allograft rejection, and tumor immunity. Adv Immunol. 1974;18:67–132. doi: 10.1016/s0065-2776(08)60308-9. [DOI] [PubMed] [Google Scholar]
  7. Chesebro B., Wehrly K., Stimpfling J. Host genetic control of recovery from Friend leukemia virus-induced splenomegaly: mapping of a gene within the major histocompatability complex. J Exp Med. 1974 Dec 1;140(6):1457–1467. doi: 10.1084/jem.140.6.1457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Chesebro B., Wehrly K. Studies on the role of the host immune response in recovery from Friend virus leukemia. I. Antiviral and antileukemia cell antibodies. J Exp Med. 1976 Jan 1;143(1):73–84. doi: 10.1084/jem.143.1.73. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Doherty P. C., Zinkernagel R. M. H-2 compatibility is required for T-cell-mediated lysis of target cells infected with lymphocytic choriomeningitis virus. J Exp Med. 1975 Feb 1;141(2):502–507. doi: 10.1084/jem.141.2.502. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Evans R., Grant C. K., Cox H., Steele K., Alexander P. Thymus-derived lymphocytes produce an immunologically specific macrophage-arming factor. J Exp Med. 1972 Nov 1;136(5):1318–1322. doi: 10.1084/jem.136.5.1318. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Freedman H. A., Lilly F. Properties of cell lines derived from tumors induced by Friend virus in BALB/c and BALB/c-H-2b mice. J Exp Med. 1975 Jul 1;142(1):212–223. doi: 10.1084/jem.142.1.212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Gorczynski R. M. Evidence for in vivo protection against murine-sarcoma virus-induced tumors by T lymphocytes from immune animals. J Immunol. 1974 Feb;112(2):533–539. [PubMed] [Google Scholar]
  13. Hellström K. E., Hellström I. Lymphocyte-mediated cytotoxicity and blocking serum activity to tumor antigens. Adv Immunol. 1974;18:209–277. doi: 10.1016/s0065-2776(08)60311-9. [DOI] [PubMed] [Google Scholar]
  14. Herberman R. B., Aoki T., Nunn M., Lavrin D. H., Soares N., Gazdar A., Holden H., Chang K. S. Specificity of 51Cr-release cytotoxicity of lymphocytes immune to murine sarcoma virus. J Natl Cancer Inst. 1974 Oct;53(4):1103–1111. doi: 10.1093/jnci/53.4.1103. [DOI] [PubMed] [Google Scholar]
  15. Herberman R. B. Cell-mediated immunity to tumor cells. Adv Cancer Res. 1974;19(0):207–263. doi: 10.1016/s0065-230x(08)60055-x. [DOI] [PubMed] [Google Scholar]
  16. KLEIN G., SJOGREN H. O., KLEIN E., HELLSTROM K. E. Demonstration of resistance against methylcholanthrene-induced sarcomas in the primary autochthonous host. Cancer Res. 1960 Dec;20:1561–1572. [PubMed] [Google Scholar]
  17. Kirchner H., Muchmore A. V., Chused T. M., Holden H. T., Herberman R. B. Inhibition of proliferation of lymphoma cells and T lymphocytes by suppressor cells from spleens of tumor-bearing mice. J Immunol. 1975 Jan;114(1 Pt 1):206–210. [PubMed] [Google Scholar]
  18. Lavrin D. H., Herberman R. B., Nunn M., Soares N. In vitro cytotoxicity studies of murine sarcoma virus-induced immunity in mice. J Natl Cancer Inst. 1973 Nov;51(5):1497–1508. doi: 10.1093/jnci/51.5.1497. [DOI] [PubMed] [Google Scholar]
  19. Leclerc J. C., Gomard E., Levy J. P. Cell-mediated reaction against tumors induced by oncornaviruses. I. Kinetics and specificity of the immune response in murine sarcoma virus (MSV)-induced tumors and transplanted lymphomas. Int J Cancer. 1972 Nov;10(3):589–601. doi: 10.1002/ijc.2910100318. [DOI] [PubMed] [Google Scholar]
  20. Lilly F. Fv-2: identification and location of a second gene governing the spleen focus response to Friend leukemia virus in mice. J Natl Cancer Inst. 1970 Jul;45(1):163–169. [PubMed] [Google Scholar]
  21. Lilly F., Steeves R. A. B-tropic Friend virus: a host-range pseudotype of spleen focus-forming virus (SFFV). Virology. 1973 Oct;55(2):363–370. doi: 10.1016/0042-6822(73)90176-1. [DOI] [PubMed] [Google Scholar]
  22. Lilly F. The effect of histocompatibility-2 type on response to friend leukemia virus in mice. J Exp Med. 1968 Mar 1;127(3):465–473. doi: 10.1084/jem.127.3.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Lodmell D. L., Notkins A. L. Cellular immunity to herpes simplex virus mediated by interferon. J Exp Med. 1974 Sep 1;140(3):764–778. doi: 10.1084/jem.140.3.764. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. MITCHISON N. A. Passive transfer of transplantation immunity. Proc R Soc Lond B Biol Sci. 1954 Feb 18;142(906):72–87. doi: 10.1098/rspb.1954.0007. [DOI] [PubMed] [Google Scholar]
  25. Mauel J., Rudolf H., Chapuis B., Brunner K. T. Studies of allograft immunity in mice. II. Mechanism of target cell inactivation in vitro by sensitized lymphocytes. Immunology. 1970 Apr;18(4):517–535. [PMC free article] [PubMed] [Google Scholar]
  26. ODAKA T., EDAKA T., YAMAMOTTO T. Inheritance of susceptibility to Friend mouse leukemia virus. Jpn J Exp Med. 1962 Oct;32:405–413. [PubMed] [Google Scholar]
  27. Pearson G. R., Redmon L. W., Bass L. R. Protective effect of immune sera against transplantable Moloney virus-induced sarcoma and lymphoma. Cancer Res. 1973 Jan;33(1):171–178. [PubMed] [Google Scholar]
  28. Perlmann P., Holm G. Cytotoxic effects of lymphoid cells in vitro. Adv Immunol. 1969;11:117–193. doi: 10.1016/s0065-2776(08)60479-4. [DOI] [PubMed] [Google Scholar]
  29. Plata F., Gomard E., Leclerc J. C., Levy J. P. Comparative in vitro studies on effector cell diversity in the cellular immune response to murine sarcoma virus (MSV)-induced tumors in mice. J Immunol. 1974 Apr;112(4):1477–1487. [PubMed] [Google Scholar]
  30. REIF A. E., ALLEN J. M. THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES. J Exp Med. 1964 Sep 1;120:413–433. doi: 10.1084/jem.120.3.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Rich M. A., Siegler R., Karl S., Clymer R. Spontaneous regression in virus-induced murine leukemia. I. Host-virus system. J Natl Cancer Inst. 1969 Apr;42(4):559–569. [PubMed] [Google Scholar]
  32. Sachs D. H., Cone J. L. A mouse B-cell alloantigen determined by gene(s) linked to the major histocompatibility complex. J Exp Med. 1973 Dec 1;138(6):1289–1304. doi: 10.1084/jem.138.6.1289. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Wright P. W., Ortiz de Landazuri M., Herberman R. B. Immune response to Gross virus-induced lymphoma: comparison of two in vitro assays of cell-mediated immunity. J Natl Cancer Inst. 1973 Apr;50(4):947–954. doi: 10.1093/jnci/50.4.947. [DOI] [PubMed] [Google Scholar]
  34. Youdim S., Moser M., Stutman O. Nonspecific suppression of tumor growth by an immune reaction to Listeria monocytogenes. J Natl Cancer Inst. 1974 Jan;52(1):193–198. doi: 10.1093/jnci/52.1.193. [DOI] [PubMed] [Google Scholar]

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