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. 1976 Feb 1;143(2):450–455. doi: 10.1084/jem.143.2.450

A single genetic element in H-2K affects mouse T-cell antiviral function in poxvirus infection

PMCID: PMC2190124  PMID: 55454

Abstract

Cell transfer experiments using mice with recombinant H-2 haplotypes were used to map the H-2 regions which must be shared by ectromelia- immune T-cell donors and virus-infected recipients for transfer of virus clearance mechanisms in the spleen. K- or D-region genes were necessary and sufficient; I-region genes were not involved. The remainder of the mouse genome could be varied widely without impairing the efficacy of T-cell antiviral function, provided either a K or a D region was shared in the donor-receipient combination. A mutation in a single genetic element of the K region of the H-2 complex abolished the antiviral effect of immune T-cell transfer in a donor-recipient combination which shared the K end.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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