Abstract
A positive correlation was found between genetic predisposition to diabetes in the mouse and susceptibility to group B Coxsackie virus in this host. Male mice of the inbred strain C57BL/Ks and the following genetic variants were used; mice homozygous for the autosomal recessive gene for diabetes (db/db), the phenotypically normal heterozygous (db/+), and the normal mice which lacked the diabetic gene (+/+). The mortality response of the +/+ mice to intraperitoneal inoculation with Coxsackie virus B4 differed from the response of the two genetic variants (db/db and db/+) derived from this strain. The db/+ variant was more susceptible to Coxsackie virus B4 than the parental background strain (+/+). The db/db variant was more susceptible than either of the other genotypes. Pathological findings of the pancreas of the three genotypes during the acute stage of infection closely paralleled the genotypically dependent susceptibility of the host.
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Selected References
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- Boucher D. W., Notkins A. L. Virus-induced diabetes mellitus. I. Hyperglycemia and hypoinsulinemia in mice infected with encephalomyocarditis virus. J Exp Med. 1973 May 1;137(5):1226–1239. doi: 10.1084/jem.137.5.1226. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chick W. L., Lavine R. L., Like A. A. Studies in the diabetic mutant mouse. V. Glucose tolerance in mice homozygous and heterozygous for the diabetes (db) gene. Diabetologia. 1970 Jun;6(3):257–262. doi: 10.1007/BF01212235. [DOI] [PubMed] [Google Scholar]
- Chick W. L., Like A. A. Studies in the diabetic mutant mouse. 3. Physiological factors associated with alterations in beta cell proliferation. Diabetologia. 1970 Jun;6(3):243–251. doi: 10.1007/BF01212233. [DOI] [PubMed] [Google Scholar]
- Coleman D. L., Hummel K. P. Studies with the mutation, diabetes, in the mouse. Diabetologia. 1967 Apr;3(2):238–248. doi: 10.1007/BF01222201. [DOI] [PubMed] [Google Scholar]
- Coleman T. J., Taylor K. W., Gamble D. R. The development of diabetes following Coxsackie B virus infection in mice. Diabetologia. 1974 Dec;10(6):755–759. doi: 10.1007/BF01219537. [DOI] [PubMed] [Google Scholar]
- Craighead J. E. The role of viruses in the pathogenesis of pancreatic disease and diabetes mellitus. Prog Med Virol. 1975;19:161–214. [PubMed] [Google Scholar]
- DALLDORF G., GIFFORD R. Adaptation of Group B Coxsackie virus to adult mouse pancreas. J Exp Med. 1952 Nov;96(5):491–497. doi: 10.1084/jem.96.5.491. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gamble D. R., Kinsley M. L., FitzGerald M. G., Bolton R., Taylor K. W. Viral antibodies in diabetes mellitus. Br Med J. 1969 Sep 13;3(5671):627–630. doi: 10.1136/bmj.3.5671.627. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gamble D. R., Taylor K. W. Coxsackie B virus and diabetes. Br Med J. 1973 Feb 3;1(5848):289–290. doi: 10.1136/bmj.1.5848.289-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gamble D. R., Taylor K. W. Seasonal incidence of diabetes mellitus. Br Med J. 1969 Sep 13;3(5671):631–633. doi: 10.1136/bmj.3.5671.631. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hummel K. P., Dickie M. M., Coleman D. L. Diabetes, a new mutation in the mouse. Science. 1966 Sep 2;153(3740):1127–1128. doi: 10.1126/science.153.3740.1127. [DOI] [PubMed] [Google Scholar]
- KIBRICK S., BENIRSCHKE K. Severe generalized disease (encephalohepatomyocarditis) occurring in the newborn period and due to infection with Coxsackie virus, group B; evidence of intrauterine infection with this agent. Pediatrics. 1958 Nov;22(5):857–875. [PubMed] [Google Scholar]
- Like A. A., Chick W. L. Studies in the diabetic mutant mouse. I. Light microscopy and radioautography of pancreatic islets. Diabetologia. 1970 Jun;6(3):207–215. doi: 10.1007/BF01212231. [DOI] [PubMed] [Google Scholar]
- Like A. A., Chick W. L. Studies in the diabetic mutant mouse. II. Electron microscopy of pancreatic islets. Diabetologia. 1970 Jun;6(3):216–242. doi: 10.1007/BF01212232. [DOI] [PubMed] [Google Scholar]
- Loria R. M., Kibrick S., Broitman S. A. Peroral infection with group B coxsackievirus in the adult mouse: protective functions of the gut. J Infect Dis. 1974 Nov;130(5):539–543. doi: 10.1093/infdis/130.5.539. [DOI] [PubMed] [Google Scholar]
- PAPPENHEIMER A. M. Fuchsinophile granules in the tissues of mice infected with the Connecticut-5 strain of Coxsackie virus. J Exp Med. 1952 Mar;95(3):251–258. doi: 10.1084/jem.95.3.251. [DOI] [PMC free article] [PubMed] [Google Scholar]