Abstract
The total hemolytic complement (C) levels in inbred line 7 chicks and adults were lower than C levels in inbred lines 2 and 3 and in outbred chickens of the same age. In all birds, adult levels of C were obtained in 5- to 6-wk-old chickens. Analysis of F1 and F3 generations clearly showed that the C level in chickens was determined by a dominant gene(s) associated with the major histocompatibility complex. Finding this association in a nonmammal strengthens the importance of the relationship between closely linked genes controlling histocompatibility, immune responsiveness, mixed leukocyte reaction, and C activity.
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Selected References
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- BRILES W. E., McGIBBON W. H., IRWIN M. R. On multiple alleles effecting cellular antigens in the chicken. Genetics. 1950 Nov;35(6):633–652. doi: 10.1093/genetics/35.6.633. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Benedict A. A., Pollard L. W. Genetic control of immune responses in chickens. Adv Exp Med Biol. 1975;64:421–430. doi: 10.1007/978-1-4684-3261-9_42. [DOI] [PubMed] [Google Scholar]
- Curman B., Ostberg L., Sandberg L., Malmheden-Eriksson I., Stålenheim G., Rask L., Peterson P. A. H-2 linked Ss protein is C4 component of complement. Nature. 1975 Nov 20;258(5532):243–245. doi: 10.1038/258243a0. [DOI] [PubMed] [Google Scholar]
- Démant P., Capková J., Hinzová E., Vorácová B. The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement. Proc Natl Acad Sci U S A. 1973 Mar;70(3):863–864. doi: 10.1073/pnas.70.3.863. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ferreira A., Nussenzweig V. Genetic linkage between serum levels of the third component of complement and the H-2 complex. J Exp Med. 1975 Feb 1;141(2):513–517. doi: 10.1084/jem.141.2.513. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Fu S. M., Kunkel H. G., Brusman H. P., Allen F. H., Jr, Fotino M. Evidence for linkage between HL-A histocompatibility genes and those involved in the synthesis of the second component of complement. J Exp Med. 1974 Oct 1;140(4):1108–1111. doi: 10.1084/jem.140.4.1108. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Günther E., Balcarová J., Hála K., Rüde E., Hraba T. Evidence for an association between immune responsiveness of chicken to (T, G)-A--L and the major histocompatibility system. Eur J Immunol. 1974 Aug;4(8):548–553. doi: 10.1002/eji.1830040806. [DOI] [PubMed] [Google Scholar]
- Hansen T. H., Shin H. S., Shreffler D. C. Evidence for the involvement of the Ss protein of the mouse in the hemolytic complement system. J Exp Med. 1975 May 1;141(5):1216–1220. doi: 10.1084/jem.141.5.1216. [DOI] [PMC free article] [PubMed] [Google Scholar]
- JAFFE W. P., McDERMID E. M. Blood groups and splenomegaly in chick embryos. Science. 1962 Sep 21;137(3534):984–984. doi: 10.1126/science.137.3534.984. [DOI] [PubMed] [Google Scholar]
- Klein J. Many questions (and almost no answers) about the phylogenetic origin of the major histocompatibility complex. Adv Exp Med Biol. 1975;64:467–478. doi: 10.1007/978-1-4684-3261-9_47. [DOI] [PubMed] [Google Scholar]
- Lachmann P. J., Grennan D., Martin A., Demant P. Identification of Ss protein as murine C4. Nature. 1975 Nov 20;258(5532):242–243. doi: 10.1038/258242a0. [DOI] [PubMed] [Google Scholar]
- Miggiano V. C., Birgen I., Pink J. R. The mixed leukocyte reaction in chickens. Evidence for control by the major histocompatibility complex. Eur J Immunol. 1974 Jun;4(6):397–401. doi: 10.1002/eji.1830040602. [DOI] [PubMed] [Google Scholar]
- SCHIERMAN L. W., NORDSKOG A. W. Influence of the B bloodgroup-histocompatibility locus in chickens on a graft-versus-host reaction. Nature. 1963 Feb 2;197:511–512. doi: 10.1038/197511a0. [DOI] [PubMed] [Google Scholar]
- SCHIERMAN L. W., NORDSKOG A. W. Relationship of blood type to histocompatibility in chickens. Science. 1961 Oct 6;134(3484):1008–1009. doi: 10.1126/science.134.3484.1008. [DOI] [PubMed] [Google Scholar]