Abstract
Lymphocytes from tx-mutant mice have a definite and consistent pattern of reactivity in MLR. Cells from t-mutant mice within a complementation group usually fail to stimulate each other, while cells from mutants in different complementation groups stimulate each other strongly. This indicates that tx-mutant types are associated with certain H-2 haplotypes, and that members of any give complementation group share the same H-2 haplotype.
Full Text
The Full Text of this article is available as a PDF (363.8 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bach F. H., Widmer M. B., Segall M., Bach M. L., Klein J. Genetic and immunological complexity of major histocompatibility regions. Science. 1972 Jun 2;176(4038):1024–1027. doi: 10.1126/science.176.4038.1024. [DOI] [PubMed] [Google Scholar]
- Benacerraf B., McDevitt H. O. Histocompatibility-linked immune response genes. Science. 1972 Jan 21;175(4019):273–279. doi: 10.1126/science.175.4019.273. [DOI] [PubMed] [Google Scholar]
- Bennett D., Goldberg E., Dunn L. C., Boyse E. A. Serological detection of a cell-surface antigen specified by the T (brachyury) mutant gene in the house mouse. Proc Natl Acad Sci U S A. 1972 Aug;69(8):2076–2080. doi: 10.1073/pnas.69.8.2076. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dunn L. C. A Third Lethal in the T (Brachy) Series in the House Mouse. Proc Natl Acad Sci U S A. 1937 Sep;23(9):474–477. doi: 10.1073/pnas.23.9.474. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gluecksohn-Waelsch S., Erickson R. P. The T-locus of the mouse: implications for mechanisms of development. Curr Top Dev Biol. 1970;5:281–316. doi: 10.1016/s0070-2153(08)60058-7. [DOI] [PubMed] [Google Scholar]
- Hammerberg C., Klein J. Linkage disequilibrium between H-2 and t complexes in chromosome 17 of the mouse. Nature. 1975 Nov 27;258(5533):296–299. doi: 10.1038/258296a0. [DOI] [PubMed] [Google Scholar]
- Klein J., Park J. M. Graft-versus-host reactions across different regions of the H-2 complex of the mouse. J Exp Med. 1973 May 1;137(5):1213–1225. doi: 10.1084/jem.137.5.1213. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Snell G. D. The H-2 locus of the mouse: observations and speculations concerning its comparative genetics and its polymorphism. Folia Biol (Praha) 1968;14(5):335–358. [PubMed] [Google Scholar]