Abstract
Mice produced reaginic antibody within 1 wk of painting with the contact sensitizing agent picryl chloride. The titers, measured by passive cutaneous anaphylaxis in rats, increased after repeated applications of picryl chloride. In contrast, serum agglutinins did not increase after two applications of picryl chloride. Reagin was also elicited by another contact sensitizing agent, oxazolone. Some strain variation of the response to picryl chloride was found, with CBA mice being good responders and BALB/c and C57BL/10 mice being poor responders.
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Selected References
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- Asherson G. L., Ptak W. Contact and delayed hypersensitivity in the mouse. I. Active sensitization and passive transfer. Immunology. 1968 Sep;15(3):405–416. [PMC free article] [PubMed] [Google Scholar]
- Asherson G. L., Zembala M. Contact sensitivity in the mouse. IV. The role of lymphocytes and macrophages in passive transfer and the mechanism of their interaction. J Exp Med. 1970 Jul 1;132(1):1–15. doi: 10.1084/jem.132.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Askenase P. W. Cutaneous basophil hypersensitivity in contact-sensitized guinea pigs. I. Transfer with immune serum. J Exp Med. 1973 Nov 1;138(5):1144–1155. doi: 10.1084/jem.138.5.1144. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Blanden R. V., Hapel A. J., Jackson D. C. Mode of action of Ir genes and the nature of T cell receptors for antigen. Immunochemistry. 1976 Feb;13(2):179–191. doi: 10.1016/0019-2791(76)90287-1. [DOI] [PubMed] [Google Scholar]
- Dvorak H. F., Simpson B. A., Bast R. C., Jr, Leskowitz S. Cutaneous basophil hypersensitivity. 3. Participation of the basophil in hypersensitivity to antigen-antibody complexes, delayed hypersensitivity and contact allergy. Passive transfer. J Immunol. 1971 Jul;107(1):138–148. [PubMed] [Google Scholar]
- Gershon R. K., Askenase P. W., Gershon M. D. Requirement for vasoactive amines for production of delayed-type hypersensitvity skin reactions. J Exp Med. 1975 Sep 1;142(3):732–747. doi: 10.1084/jem.142.3.732. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kind L. S., Macedo-Sobrinho B. Communications. Heterologous adoptive cutaneous anaphylaxis: a method for detecting reaginic antibody formation by cells of the mouse. J Immunol. 1973 Aug;111(2):638–640. [PubMed] [Google Scholar]
- Levine B. B., Vaz N. M. Effect of combinations of inbred strain, antigen, and antigen dose on immune responsiveness and reagin production in the mouse. A potential mouse model for immune aspects of human atopic allergy. Int Arch Allergy Appl Immunol. 1970;39(2-3):156–171. doi: 10.1159/000230343. [DOI] [PubMed] [Google Scholar]
- Mota I., Wong D. Homologous and heterologous passive cutaneous anaphylactic activity of mouse antisera during the course of immunization. Life Sci. 1969 Aug 15;8(16):813–820. doi: 10.1016/0024-3205(69)90099-x. [DOI] [PubMed] [Google Scholar]
- Rittenberg M. B., Amkraut A. A. Immunogenicity of trinitrophenyl-hemocyanin: production of primary and secondary anti-hapten precipitins. J Immunol. 1966 Sep;97(3):421–430. [PubMed] [Google Scholar]
- Rittenberg M. B., Pratt K. L. Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen. Proc Soc Exp Biol Med. 1969 Nov;132(2):575–581. doi: 10.3181/00379727-132-34264. [DOI] [PubMed] [Google Scholar]
- Rocklin R. E. Modulation of cellular-immune responses in vivo and in vitro by histamine receptor-bearing lymphocytes. J Clin Invest. 1976 Apr;57(4):1051–1058. doi: 10.1172/JCI108347. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tada T. Regulation of reaginic antibody formation in animals. Prog Allergy. 1975;19:122–194. [PubMed] [Google Scholar]
- Yoshimura M., Cinader B. The effect of tolerance on the specificity of the antibody response: antibody to oxazolonated albumin of animals tolerant to the protein carrier. J Immunol. 1966 Dec;97(6):959–968. [PubMed] [Google Scholar]