Abstract
Normal spleen cells cultured with TNP-modified syngeneic spleen cells fail to mount an anti-TNP PFC response to TNP-ficoll or TNP-red blood cells,but go on to generate cytotoxic T cells directed at hapten- modified H-2.These results suggest that hapten-modifeid spleen cells may differentially induce B-cell tolerance and T- (Ly 2,3) cell immunity. The differential response to modified self by lymphocyte subpopulations is discussed.
Full Text
The Full Text of this article is available as a PDF (361.3 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Aldo-Benson M., Borel Y. Loss of carrier-determined tolerance in vitro with loss of receptor blockade. J Immunol. 1976 Jan;116(1):223–226. [PubMed] [Google Scholar]
- Battisto J. R., Bloom B. R. Mechanism of immunologic unresponsiveness: a new approach. Fed Proc. 1966 Jan-Feb;25(1):152–159. [PubMed] [Google Scholar]
- Berke G., Amos D. B. Mechanism of lymphocyte-mediated cytolysis. The LMC cycle and its role in transplantation immunity. Transplant Rev. 1973;17(0):71–107. doi: 10.1111/j.1600-065x.1973.tb00124.x. [DOI] [PubMed] [Google Scholar]
- Claman H. N. Tolerance and contact sensitivity to DNFB in mice. V. Induction of tolerance with DNP compounds and with free and membrane-associated DNFB. J Immunol. 1976 Mar;116(3):704–709. [PubMed] [Google Scholar]
- Cunningham A. J. Active suppressor mechanism maintaining tolerance to some self components. Nature. 1975 Mar 13;254(5496):143–144. doi: 10.1038/254143a0. [DOI] [PubMed] [Google Scholar]
- Cunningham A. J., Szenberg A. Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology. 1968 Apr;14(4):599–600. [PMC free article] [PubMed] [Google Scholar]
- Golan D. T., Borel Y. Nonantigenicity and immunologic tolerance: the role of the carrier in the induction of tolerance to the hapten. J Exp Med. 1971 Oct 1;134(4):1046–1061. doi: 10.1084/jem.134.4.1046. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hamilton J. A., Miller J. F. Hapten-specific tolerance: unresponsiveness in the T cell-depleted population. Eur J Immunol. 1973 Jul;3(7):457–460. doi: 10.1002/eji.1830030716. [DOI] [PubMed] [Google Scholar]
- Havas H. F. The effect of the carrier protein on the immune response and on the induction of tolerance in mice to the 2,4-dinitrophenyl determinant. Immunology. 1969 Dec;17(6):819–829. [PMC free article] [PubMed] [Google Scholar]
- Howard J. C., Hunt S. V., Gowans J. L. Identification of marrow-derived and thymus-derived small lymphocytes in the lymphoid tissue and thoracic duct lymph of normal rats. J Exp Med. 1972 Feb 1;135(2):200–219. doi: 10.1084/jem.135.2.200. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Huber B., Devinsky O., Gershon R. K., Cantor H. Cell-mediated immunity: delayed-type hypersensitivity and cytotoxic responses are mediated by different T-cell subclasses. J Exp Med. 1976 Jun 1;143(6):1534–1539. doi: 10.1084/jem.143.6.1534. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kettman J., Dutton R. W. Radioresistance of the enhancing effect of cells from carrier-immunized mice in an in vitro primary immune response. Proc Natl Acad Sci U S A. 1971 Apr;68(4):699–703. doi: 10.1073/pnas.68.4.699. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Naor D., Mishell R. I., Wofsy L. Specific inhibition of an anti-hapten immune response by chemical modifications of cells. J Immunol. 1970 Dec;105(6):1322–1326. [PubMed] [Google Scholar]
- Scott D. W. Antifluorescein affinity columns. Isolation and immunocompetence of lymphocytes that bind fluoresceinated antigens in vivo or in vitro. J Exp Med. 1976 Jul 1;144(1):69–78. doi: 10.1084/jem.144.1.69. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Walters C. S., Claman H. N. Immunologic reactions to haptens on autologous carriers. II. Induction of hapten-specific tolerance and correlations between antibody response and antigen-driven cell proliferation in vitro. J Immunol. 1974 Aug;113(2):645–653. [PubMed] [Google Scholar]