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. 1985 Jul;163(1):389–391. doi: 10.1128/jb.163.1.389-391.1985

Generation of purpura-producing principle from pneumococcal cell walls.

C Chetty, A Kreger
PMCID: PMC219126  PMID: 4008446

Abstract

The in vitro kinetics of muramic acid-alanine bond hydrolysis and pneumococcal purpura-producing principle generation by incubation of Streptococcus pneumoniae cell wall preparations with the bacterial autolysin N-acetylmuramyl-L-alanine amidase were similar. The generated purpura-producing principle preparation had a weight-average molecular weight of ca. 2.6 X 10(7) and possessed the glycan and teichoic acid constituents of the pneumococcal cell wall. The results support the idea that the pneumococcal purpura-producing principle is a high-molecular-weight, glycan-teichoic acid fragment released by hydrolysis of the muramic acid-alanine bonds in the bacterial cell wall.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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