Abstract
A gene that regulates the hemolysin structural gene (hly) was found to be tightly linked to the tox-1000 locus of Vibrio cholerae RJ1 and separated from hly by a large section of the V. cholerae genetic map. This hemolysin regulatory gene was designated hlyR.
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Selected References
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- Baine W. B., Vasil M. L., Holmes R. K. Genetic mapping of mutations in independently isolated nontoxinogenic mutants of Vibrio cholerae. Infect Immun. 1978 Jul;21(1):194–200. doi: 10.1128/iai.21.1.194-200.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bramucci M. G., Holmes R. K. Radial passive immune hemolysis assay for detection of heat-labile enterotoxin produced by individual colonies of Escherichia coli or Vibrio cholerae. J Clin Microbiol. 1978 Aug;8(2):252–255. doi: 10.1128/jcm.8.2.252-255.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bramucci M. G., Twiddy E. M., Baine W. B., Holmes R. K. Isolation and characterization of hypertoxinogenic (htx) mutants of Escherichia coli KL320(pCG86). Infect Immun. 1981 Jun;32(3):1034–1044. doi: 10.1128/iai.32.3.1034-1044.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brown M. R., Foster J. H. A simple diagnostic milk medium for Pseudomonas aeruginosa. J Clin Pathol. 1970 Mar;23(2):172–177. doi: 10.1136/jcp.23.2.172. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Finkelstein R. A., Vasil M. L., Holmes R. K. Studies on toxinogenesis in Vibrio cholerae. I. Isolation of mutants with altered toxinogenicity. J Infect Dis. 1974 Feb;129(2):117–123. doi: 10.1093/infdis/129.2.117. [DOI] [PubMed] [Google Scholar]
- Goldberg S. L., Murphy J. R. Molecular cloning of the hemolysin determinant from Vibrio cholerae El Tor. J Bacteriol. 1984 Oct;160(1):239–244. doi: 10.1128/jb.160.1.239-244.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hanne L. F., Finkelstein R. A. Characterization and distribution of the hemagglutinins produced by Vibrio cholerae. Infect Immun. 1982 Apr;36(1):209–214. doi: 10.1128/iai.36.1.209-214.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LOVELESS A., HOWARTH S. Mutation of bacteria at high levels of survival by ethyl methane sulphonate. Nature. 1959 Dec 5;184:1780–1782. doi: 10.1038/1841780a0. [DOI] [PubMed] [Google Scholar]
- Lockman H., Kaper J. B. Nucleotide sequence analysis of the A2 and B subunits of Vibrio cholerae enterotoxin. J Biol Chem. 1983 Nov 25;258(22):13722–13726. [PubMed] [Google Scholar]
- Merson M. H., Martin W. T., Craig J. P., Morris G. K., Blake P. A., Craun G. F., Feeley J. C., Camacho J. C., Gangarosa E. J. Cholera on Guam, 1974: epidemiologic findings and isolation of non-toxinogenic strains. Am J Epidemiol. 1977 Apr;105(4):349–361. doi: 10.1093/oxfordjournals.aje.a112393. [DOI] [PubMed] [Google Scholar]
- Miller V. L., Mekalanos J. J. Synthesis of cholera toxin is positively regulated at the transcriptional level by toxR. Proc Natl Acad Sci U S A. 1984 Jun;81(11):3471–3475. doi: 10.1073/pnas.81.11.3471. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Parker C., Gauthier D., Tate A., Richardson K., Romig W. R. Expanded linkage map of Vibrio cholerae. Genetics. 1979 Feb;91(2):191–214. doi: 10.1093/genetics/91.2.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Saunders D. W., Bramucci M. G. Genetic mapping of the tox-1000 locus of Vibrio cholerae El Tor strain RJ1. Infect Immun. 1983 May;40(2):829–831. doi: 10.1128/iai.40.2.829-831.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Saunders D. W., Kubala G. J., Vaidya A. B., Bramucci M. G. Evidence indicating that the cholera toxin structural genes of Vibrio cholerae RJ1 and 3083-2 are between met and trp. Infect Immun. 1983 Oct;42(1):427–430. doi: 10.1128/iai.42.1.427-430.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Saunders D. W., Schanbacher K. J., Bramucci M. G. Mapping of a gene in Vibrio cholerae that determines the antigenic structure of cholera toxin. Infect Immun. 1982 Dec;38(3):1109–1116. doi: 10.1128/iai.38.3.1109-1116.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sporecke I., Castro D., Mekalanos J. J. Genetic mapping of Vibrio cholerae enterotoxin structural genes. J Bacteriol. 1984 Jan;157(1):253–261. doi: 10.1128/jb.157.1.253-261.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sublett R. D., Romig W. R. Transposon-facilitated recombination in classical biotypes of Vibrio cholerae. Infect Immun. 1981 Jun;32(3):1132–1138. doi: 10.1128/iai.32.3.1132-1138.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vasil M. L., Holmes R. K., Finkelstein R. A. Conjugal transfer of a chromosomal gene determining production of enterotoxin in vibrio cholerae. Science. 1975 Mar 7;187(4179):849–850. doi: 10.1126/science.1114331. [DOI] [PubMed] [Google Scholar]