Skip to main content

Some NLM-NCBI services and products are experiencing heavy traffic, which may affect performance and availability. We apologize for the inconvenience and appreciate your patience. For assistance, please contact our Help Desk at info@ncbi.nlm.nih.gov.

The Journal of Experimental Medicine logoLink to The Journal of Experimental Medicine
. 1995 Sep 1;182(3):633–638. doi: 10.1084/jem.182.3.633

NK1.1+ T cell receptor-alpha/beta+ cells: new clues to their origin, specificity, and function

PMCID: PMC2192172  PMID: 7650474

Full Text

The Full Text of this article is available as a PDF (702.3 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adachi Y., Koseki H., Zijlstra M., Taniguchi M. Positive selection of invariant V alpha 14+ T cells by non-major histocompatibility complex-encoded class I-like molecules expressed on bone marrow-derived cells. Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):1200–1204. doi: 10.1073/pnas.92.4.1200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Arase H., Arase N., Kobayashi Y., Nishimura Y., Yonehara S., Onoé K. Cytotoxicity of fresh NK1.1+ T cell receptor alpha/beta+ thymocytes against a CD4+8+ thymocyte population associated with intact Fas antigen expression on the target. J Exp Med. 1994 Aug 1;180(2):423–432. doi: 10.1084/jem.180.2.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Arase H., Arase N., Nakagawa K., Good R. A., Onoé K. NK1.1+ CD4+ CD8- thymocytes with specific lymphokine secretion. Eur J Immunol. 1993 Jan;23(1):307–310. doi: 10.1002/eji.1830230151. [DOI] [PubMed] [Google Scholar]
  4. Arase H., Arase N., Ogasawara K., Good R. A., Onoé K. An NK1.1+ CD4+8- single-positive thymocyte subpopulation that expresses a highly skewed T-cell antigen receptor V beta family. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6506–6510. doi: 10.1073/pnas.89.14.6506. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Arase H., Ono S., Arase N., Park S. Y., Wakizaka K., Watanabe H., Ohno H., Saito T. Developmental arrest of NK1.1+ T cell antigen receptor (TCR)-alpha/beta+ T cells and expansion of NK1.1+ TCR-gamma/delta+ T cell development in CD3 zeta-deficient mice. J Exp Med. 1995 Sep 1;182(3):891–895. doi: 10.1084/jem.182.3.891. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ballas Z. K., Rasmussen W. Lymphokine-activated killer cells. VII. IL-4 induces an NK1.1+CD8 alpha+beta- TCR-alpha beta B220+ lymphokine-activated killer subset. J Immunol. 1993 Jan 1;150(1):17–30. [PubMed] [Google Scholar]
  7. Ballas Z. K., Rasmussen W. NK1.1+ thymocytes. Adult murine CD4-, CD8- thymocytes contain an NK1.1+, CD3+, CD5hi, CD44hi, TCR-V beta 8+ subset. J Immunol. 1990 Aug 15;145(4):1039–1045. [PubMed] [Google Scholar]
  8. Barbo J. V., McCormack J. E., Moorhead J. W., Fairchild R. L. Reconstitution of TCR alpha-chain expression in deletion mutants restores dinitrophenyl-specific/class I MHC-restricted suppressor molecule production. J Immunol. 1995 Feb 15;154(4):1551–1559. [PubMed] [Google Scholar]
  9. Beckman E. M., Porcelli S. A., Morita C. T., Behar S. M., Furlong S. T., Brenner M. B. Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells. Nature. 1994 Dec 15;372(6507):691–694. doi: 10.1038/372691a0. [DOI] [PubMed] [Google Scholar]
  10. Bendelac A., Killeen N., Littman D. R., Schwartz R. H. A subset of CD4+ thymocytes selected by MHC class I molecules. Science. 1994 Mar 25;263(5154):1774–1778. doi: 10.1126/science.7907820. [DOI] [PubMed] [Google Scholar]
  11. Bendelac A., Lantz O., Quimby M. E., Yewdell J. W., Bennink J. R., Brutkiewicz R. R. CD1 recognition by mouse NK1+ T lymphocytes. Science. 1995 May 12;268(5212):863–865. doi: 10.1126/science.7538697. [DOI] [PubMed] [Google Scholar]
  12. Benveniste P., Chadwick B. S., Miller R. G., Reimann J. Characterization of cells with T cell markers in athymic nude bone marrow and of their in vitro-derived clonal progeny. Comparison with euthymic bone marrow. J Immunol. 1990 Jan 15;144(2):411–419. [PubMed] [Google Scholar]
  13. Bezouska K., Yuen C. T., O'Brien J., Childs R. A., Chai W., Lawson A. M., Drbal K., Fiserová A., Pospísil M., Feizi T. Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity. Nature. 1994 Nov 10;372(6502):150–157. doi: 10.1038/372150a0. [DOI] [PubMed] [Google Scholar]
  14. Bix M., Coles M., Raulet D. Positive selection of V beta 8+ CD4-8- thymocytes by class I molecules expressed by hematopoietic cells. J Exp Med. 1993 Sep 1;178(3):901–908. doi: 10.1084/jem.178.3.901. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Bradbury A., Calabi F., Milstein C. Expression of CD1 in the mouse thymus. Eur J Immunol. 1990 Aug;20(8):1831–1836. doi: 10.1002/eji.1830200830. [DOI] [PubMed] [Google Scholar]
  16. Brennan J., Mager D., Jefferies W., Takei F. Expression of different members of the Ly-49 gene family defines distinct natural killer cell subsets and cell adhesion properties. J Exp Med. 1994 Dec 1;180(6):2287–2295. doi: 10.1084/jem.180.6.2287. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Brissette-Storkus C., Kaufman C. L., Pasewicz L., Worsey H. M., Lakomy R., Ildstad S. T., Chambers W. H. Characterization and function of the NKR-P1dim/T cell receptor-alpha beta+ subset of rat T cells. J Immunol. 1994 Jan 15;152(2):388–396. [PubMed] [Google Scholar]
  18. Budd R. C., Miescher G. C., Howe R. C., Lees R. K., Bron C., MacDonald H. R. Developmentally regulated expression of T cell receptor beta chain variable domains in immature thymocytes. J Exp Med. 1987 Aug 1;166(2):577–582. doi: 10.1084/jem.166.2.577. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Coles M. C., Raulet D. H. Class I dependence of the development of CD4+ CD8- NK1.1+ thymocytes. J Exp Med. 1994 Jul 1;180(1):395–399. doi: 10.1084/jem.180.1.395. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Colonna M., Samaridis J. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science. 1995 Apr 21;268(5209):405–408. doi: 10.1126/science.7716543. [DOI] [PubMed] [Google Scholar]
  21. Crispe I. N., Huang L. Neonatal, moribund and undead T cells: the role of the liver in T cell development. Semin Immunol. 1994 Feb;6(1):39–41. doi: 10.1006/smim.1994.1006. [DOI] [PubMed] [Google Scholar]
  22. Dejbakhsh-Jones S., Okazaki H., Strober S. Similar rates of production of T and B lymphocytes in the bone marrow. J Exp Med. 1995 Jun 1;181(6):2201–2211. doi: 10.1084/jem.181.6.2201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Ferrini S., Cambiaggi A., Meazza R., Sforzini S., Marciano S., Mingari M. C., Moretta L. T cell clones expressing the natural killer cell-related p58 receptor molecule display heterogeneity in phenotypic properties and p58 function. Eur J Immunol. 1994 Oct;24(10):2294–2298. doi: 10.1002/eji.1830241005. [DOI] [PubMed] [Google Scholar]
  24. Fowlkes B. J., Kruisbeek A. M., Ton-That H., Weston M. A., Coligan J. E., Schwartz R. H., Pardoll D. M. A novel population of T-cell receptor alpha beta-bearing thymocytes which predominantly expresses a single V beta gene family. Nature. 1987 Sep 17;329(6136):251–254. doi: 10.1038/329251a0. [DOI] [PubMed] [Google Scholar]
  25. Georgopoulos K., Bigby M., Wang J. H., Molnar A., Wu P., Winandy S., Sharpe A. The Ikaros gene is required for the development of all lymphoid lineages. Cell. 1994 Oct 7;79(1):143–156. doi: 10.1016/0092-8674(94)90407-3. [DOI] [PubMed] [Google Scholar]
  26. Gollob K. J., Coffman R. L. A minority subpopulation of CD4+ T cells directs the development of naive CD4+ T cells into IL-4-secreting cells. J Immunol. 1994 Jun 1;152(11):5180–5188. [PubMed] [Google Scholar]
  27. Green D. R., Webb D. R. Saying the 'S' word in public. Immunol Today. 1993 Nov;14(11):523–525. doi: 10.1016/0167-5699(93)90180-S. [DOI] [PubMed] [Google Scholar]
  28. Hashimoto W., Takeda K., Anzai R., Ogasawara K., Sakihara H., Sugiura K., Seki S., Kumagai K. Cytotoxic NK1.1 Ag+ alpha beta T cells with intermediate TCR induced in the liver of mice by IL-12. J Immunol. 1995 May 1;154(9):4333–4340. [PubMed] [Google Scholar]
  29. Holcombe H. R., Castaño A. R., Cheroutre H., Teitell M., Maher J. K., Peterson P. A., Kronenberg M. Nonclassical behavior of the thymus leukemia antigen: peptide transporter-independent expression of a nonclassical class I molecule. J Exp Med. 1995 Apr 1;181(4):1433–1443. doi: 10.1084/jem.181.4.1433. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Kikly K., Dennert G. Evidence for a role for T cell receptors (TCR) in the effector phase of acute bone marrow graft rejection. TCR V beta 5 transgenic mice lack effector cells able to cause graft rejection. J Immunol. 1992 Dec 1;149(11):3489–3494. [PubMed] [Google Scholar]
  31. Kikly K., Dennert G. Evidence for extrathymic development of TNK cells. NK1+ CD3+ cells responsible for acute marrow graft rejection are present in thymus-deficient mice. J Immunol. 1992 Jul 15;149(2):403–412. [PubMed] [Google Scholar]
  32. Koo G. C., Peppard J. R. Establishment of monoclonal anti-Nk-1.1 antibody. Hybridoma. 1984 Fall;3(3):301–303. doi: 10.1089/hyb.1984.3.301. [DOI] [PubMed] [Google Scholar]
  33. Koseki H., Asano H., Inaba T., Miyashita N., Moriwaki K., Lindahl K. F., Mizutani Y., Imai K., Taniguchi M. Dominant expression of a distinctive V14+ T-cell antigen receptor alpha chain in mice. Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7518–7522. doi: 10.1073/pnas.88.17.7518. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Koseki H., Imai K., Ichikawa T., Hayata I., Taniguchi M. Predominant use of a particular alpha-chain in suppressor T cell hybridomas specific for keyhole limpet hemocyanin. Int Immunol. 1989;1(6):557–564. doi: 10.1093/intimm/1.6.557. [DOI] [PubMed] [Google Scholar]
  35. Koyasu S. CD3+CD16+NK1.1+B220+ large granular lymphocytes arise from both alpha-beta TCR+CD4-CD8- and gamma-delta TCR+CD4-CD8- cells. J Exp Med. 1994 Jun 1;179(6):1957–1972. doi: 10.1084/jem.179.6.1957. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Kubota H., Okazaki H., Onuma M., Kano S., Hattori M., Minato N. CD3+4-8- alpha beta T cell population with biased T cell receptor V gene usage. Presence in bone marrow and possible involvement of IL-3 for their extrathymic development. J Immunol. 1992 Aug 15;149(4):1143–1150. [PubMed] [Google Scholar]
  37. Lanier L. L., Spits H., Phillips J. H. The developmental relationship between NK cells and T cells. Immunol Today. 1992 Oct;13(10):392–395. doi: 10.1016/0167-5699(92)90087-N. [DOI] [PubMed] [Google Scholar]
  38. Lantz O., Bendelac A. An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans. J Exp Med. 1994 Sep 1;180(3):1097–1106. doi: 10.1084/jem.180.3.1097. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Levitsky H. I., Golumbek P. T., Pardoll D. M. The fate of CD4-8- T cell receptor-alpha beta+ thymocytes. J Immunol. 1991 Feb 15;146(4):1113–1117. [PubMed] [Google Scholar]
  40. Liu C. P., Ueda R., She J., Sancho J., Wang B., Weddell G., Loring J., Kurahara C., Dudley E. C., Hayday A. Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine. EMBO J. 1993 Dec;12(12):4863–4875. doi: 10.1002/j.1460-2075.1993.tb06176.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  41. Makino Y., Yamagata N., Sasho T., Adachi Y., Kanno R., Koseki H., Kanno M., Taniguchi M. Extrathymic development of V alpha 14-positive T cells. J Exp Med. 1993 May 1;177(5):1399–1408. doi: 10.1084/jem.177.5.1399. [DOI] [PMC free article] [PubMed] [Google Scholar]
  42. Malissen M., Gillet A., Rocha B., Trucy J., Vivier E., Boyer C., Köntgen F., Brun N., Mazza G., Spanopoulou E. T cell development in mice lacking the CD3-zeta/eta gene. EMBO J. 1993 Nov;12(11):4347–4355. doi: 10.1002/j.1460-2075.1993.tb06119.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  43. Moretta L., Ciccone E., Mingari M. C., Biassoni R., Moretta A. Human natural killer cells: origin, clonality, specificity, and receptors. Adv Immunol. 1994;55:341–380. doi: 10.1016/s0065-2776(08)60513-1. [DOI] [PubMed] [Google Scholar]
  44. Ohno H., Ono S., Hirayama N., Shimada S., Saito T. Preferential usage of the Fc receptor gamma chain in the T cell antigen receptor complex by gamma/delta T cells localized in epithelia. J Exp Med. 1994 Jan 1;179(1):365–369. doi: 10.1084/jem.179.1.365. [DOI] [PMC free article] [PubMed] [Google Scholar]
  45. Ohteki T., MacDonald H. R. Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice. J Exp Med. 1994 Aug 1;180(2):699–704. doi: 10.1084/jem.180.2.699. [DOI] [PMC free article] [PubMed] [Google Scholar]
  46. Palathumpat V., Dejbakhsh-Jones S., Holm B., Wang H., Liang O., Strober S. Studies of CD4- CD8- alpha beta bone marrow T cells with suppressor activity. J Immunol. 1992 Jan 15;148(2):373–380. [PubMed] [Google Scholar]
  47. Phillips J. H., Gumperz J. E., Parham P., Lanier L. L. Superantigen-dependent, cell-mediated cytotoxicity inhibited by MHC class I receptors on T lymphocytes. Science. 1995 Apr 21;268(5209):403–405. doi: 10.1126/science.7716542. [DOI] [PubMed] [Google Scholar]
  48. Roland J., Cazenave P. A. Ly-49 antigen defines an alpha beta TCR population in i-IEL with an extrathymic maturation. Int Immunol. 1992 Jun;4(6):699–706. doi: 10.1093/intimm/4.6.699. [DOI] [PubMed] [Google Scholar]
  49. Ryan J. C., Niemi E. C., Nakamura M. C., Seaman W. E. NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity. J Exp Med. 1995 May 1;181(5):1911–1915. doi: 10.1084/jem.181.5.1911. [DOI] [PMC free article] [PubMed] [Google Scholar]
  50. Sato K., Ohtsuka K., Hasegawa K., Yamagiwa S., Watanabe H., Asakura H., Abo T. Evidence for extrathymic generation of intermediate T cell receptor cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation. J Exp Med. 1995 Sep 1;182(3):759–767. doi: 10.1084/jem.182.3.759. [DOI] [PMC free article] [PubMed] [Google Scholar]
  51. Singer P. A., Theofilopoulos A. N. Novel origin of lpr and gld cells and possible implications in autoimmunity. J Autoimmun. 1990 Apr;3(2):123–135. doi: 10.1016/0896-8411(90)90136-g. [DOI] [PubMed] [Google Scholar]
  52. Sykes M. Unusual T cell populations in adult murine bone marrow. Prevalence of CD3+CD4-CD8- and alpha beta TCR+NK1.1+ cells. J Immunol. 1990 Nov 15;145(10):3209–3215. [PubMed] [Google Scholar]
  53. Takeda K., Dennert G. Demonstration of MHC class I-specific cytolytic activity in IL-2-activated NK1+CD3+ cells and evidence of usage of T and NK cell receptors. Transplantation. 1994 Aug 27;58(4):496–504. doi: 10.1097/00007890-199408270-00017. [DOI] [PubMed] [Google Scholar]
  54. Trinchieri G. Biology of natural killer cells. Adv Immunol. 1989;47:187–376. doi: 10.1016/S0065-2776(08)60664-1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  55. Wagtmann N., Biassoni R., Cantoni C., Verdiani S., Malnati M. S., Vitale M., Bottino C., Moretta L., Moretta A., Long E. O. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity. 1995 May;2(5):439–449. doi: 10.1016/1074-7613(95)90025-x. [DOI] [PubMed] [Google Scholar]
  56. Yankelevich B., Knobloch C., Nowicki M., Dennert G. A novel cell type responsible for marrow graft rejection in mice. T cells with NK phenotype cause acute rejection of marrow grafts. J Immunol. 1989 May 15;142(10):3423–3430. [PubMed] [Google Scholar]
  57. Yokoyama W. M., Seaman W. E. The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Annu Rev Immunol. 1993;11:613–635. doi: 10.1146/annurev.iy.11.040193.003145. [DOI] [PubMed] [Google Scholar]
  58. Yoshimoto T., Paul W. E. CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J Exp Med. 1994 Apr 1;179(4):1285–1295. doi: 10.1084/jem.179.4.1285. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Yu Y. Y., Kumar V., Bennett M. Murine natural killer cells and marrow graft rejection. Annu Rev Immunol. 1992;10:189–213. doi: 10.1146/annurev.iy.10.040192.001201. [DOI] [PubMed] [Google Scholar]
  60. Zlotnik A., Godfrey D. I., Fischer M., Suda T. Cytokine production by mature and immature CD4-CD8- T cells. Alpha beta-T cell receptor+ CD4-CD8- T cells produce IL-4. J Immunol. 1992 Aug 15;149(4):1211–1215. [PubMed] [Google Scholar]
  61. de la Salle H., Hanau D., Fricker D., Urlacher A., Kelly A., Salamero J., Powis S. H., Donato L., Bausinger H., Laforet M. Homozygous human TAP peptide transporter mutation in HLA class I deficiency. Science. 1994 Jul 8;265(5169):237–241. doi: 10.1126/science.7517574. [DOI] [PubMed] [Google Scholar]

Articles from The Journal of Experimental Medicine are provided here courtesy of The Rockefeller University Press

RESOURCES