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. 1996 Apr 1;183(4):1297–1301. doi: 10.1084/jem.183.4.1297

Primary allergic sensitization to environmental antigens: perinatal T cell priming as a determinant of responder phenotype in adulthood

PMCID: PMC2192481  PMID: 8666887

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Selected References

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  1. Borres M. P., Einarsson R., Björkstén B. Serum levels of interleukin-4, soluble CD23 and IFN gamma in relation to the development of allergic disease during the first 18 months of life. Clin Exp Allergy. 1995 Jun;25(6):543–548. doi: 10.1111/j.1365-2222.1995.tb01092.x. [DOI] [PubMed] [Google Scholar]
  2. Chen Y., Inobe J., Marks R., Gonnella P., Kuchroo V. K., Weiner H. L. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature. 1995 Jul 13;376(6536):177–180. doi: 10.1038/376177a0. [DOI] [PubMed] [Google Scholar]
  3. Demeure C. E., Yang L. P., Byun D. G., Ishihara H., Vezzio N., Delespesse G. Human naive CD4 T cells produce interleukin-4 at priming and acquire a Th2 phenotype upon repetitive stimulations in neutral conditions. Eur J Immunol. 1995 Sep;25(9):2722–2725. doi: 10.1002/eji.1830250950. [DOI] [PubMed] [Google Scholar]
  4. Devey M. E., Beckman S., Kemeny D. M. The functional affinities of antibodies of different IgG subclasses to dietary antigens in mothers and their babies. Clin Exp Immunol. 1993 Oct;94(1):117–121. doi: 10.1111/j.1365-2249.1993.tb05987.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Friedman A., Weiner H. L. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc Natl Acad Sci U S A. 1994 Jul 5;91(14):6688–6692. doi: 10.1073/pnas.91.14.6688. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gammon G., Dunn K., Shastri N., Oki A., Wilbur S., Sercarz E. E. Neonatal T-cell tolerance to minimal immunogenic peptides is caused by clonal inactivation. 1986 Jan 30-Feb 5Nature. 319(6052):413–415. doi: 10.1038/319413a0. [DOI] [PubMed] [Google Scholar]
  7. Gregerson D. S., Obritsch W. F., Donoso L. A. Oral tolerance in experimental autoimmune uveoretinitis. Distinct mechanisms of resistance are induced by low dose vs high dose feeding protocols. J Immunol. 1993 Nov 15;151(10):5751–5761. [PubMed] [Google Scholar]
  8. Halvorsen R., Bosnes V., Thorsby E. T cell responses to a Dermatophagoides farinae allergen preparation in allergics and healthy controls. Int Arch Allergy Appl Immunol. 1986;80(1):62–69. doi: 10.1159/000234027. [DOI] [PubMed] [Google Scholar]
  9. Hattevig G., Kjellman B., Björkstén B. Appearance of IgE antibodies to ingested and inhaled allergens during the first 12 years of life in atopic and non-atopic children. Pediatr Allergy Immunol. 1993 Nov;4(4):182–186. doi: 10.1111/j.1399-3038.1993.tb00089.x. [DOI] [PubMed] [Google Scholar]
  10. Holt P. G. Environmental factors and primary T-cell sensitisation to inhalant allergens in infancy: reappraisal of the role of infections and air pollution. Pediatr Allergy Immunol. 1995 Feb;6(1):1–10. doi: 10.1111/j.1399-3038.1995.tb00250.x. [DOI] [PubMed] [Google Scholar]
  11. Holt P. G. Immunoprophylaxis of atopy: light at the end of the tunnel? Immunol Today. 1994 Oct;15(10):484–489. doi: 10.1016/0167-5699(94)90194-5. [DOI] [PubMed] [Google Scholar]
  12. Holt P. G., Schon-Hegrad M. A., Phillips M. J., McMenamin P. G. Ia-positive dendritic cells form a tightly meshed network within the human airway epithelium. Clin Exp Allergy. 1989 Nov;19(6):597–601. doi: 10.1111/j.1365-2222.1989.tb02752.x. [DOI] [PubMed] [Google Scholar]
  13. Holt P. G., Vines J., Britten D. Suppression of IgE responses by antigen inhalation: failure of tolerance mechanism(s) in newborn rats. Immunology. 1988 Apr;63(4):591–593. [PMC free article] [PubMed] [Google Scholar]
  14. Imada M., Simons F. E., Jay F. T., Hayglass K. T. Allergen-stimulated interleukin-4 and interferon-gamma production in primary culture: responses of subjects with allergic rhinitis and normal controls. Immunology. 1995 Jul;85(3):373–380. [PMC free article] [PubMed] [Google Scholar]
  15. Jarrett E. E., Hall E. IgE suppression by maternal IgG. Immunology. 1983 Jan;48(1):49–58. [PMC free article] [PubMed] [Google Scholar]
  16. Kemeny D. M., Urbanek R., Ewan P., McHugh S., Richards D., Patel S., Lessof M. H. The subclass of IgG antibody in allergic disease: II. The IgG subclass of antibodies produced following natural exposure to dust mite and grass pollen in atopic and non-atopic individuals. Clin Exp Allergy. 1989 Sep;19(5):545–549. doi: 10.1111/j.1365-2222.1989.tb02431.x. [DOI] [PubMed] [Google Scholar]
  17. Kondo N., Kobayashi Y., Shinoda S., Kasahara K., Kameyama T., Iwasa S., Orii T. Cord blood lymphocyte responses to food antigens for the prediction of allergic disorders. Arch Dis Child. 1992 Aug;67(8):1003–1007. doi: 10.1136/adc.67.8.1003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Lamont A. G., Gordon M., Ferguson A. Oral tolerance in protein-deprived mice. II. Evidence of normal 'gut processing' of ovalbumin, but suppressor cell deficiency, in deprived mice. Immunology. 1987 Jul;61(3):339–343. [PMC free article] [PubMed] [Google Scholar]
  19. Mariani F., Price J. F., Kemeny D. M. The IgG subclass antibody response to an inhalant antigen (Dermatophagoides pteronyssinus) during the first year of life: evidence for early stimulation of the immune system following natural exposure. Clin Exp Allergy. 1992 Jan;22(1):29–33. doi: 10.1111/j.1365-2222.1992.tb00111.x. [DOI] [PubMed] [Google Scholar]
  20. McMenamin C., Holt P. G. The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production. J Exp Med. 1993 Sep 1;178(3):889–899. doi: 10.1084/jem.178.3.889. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Miller A., Lider O., Roberts A. B., Sporn M. B., Weiner H. L. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):421–425. doi: 10.1073/pnas.89.1.421. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Nelson D. J., McMenamin C., McWilliam A. S., Brenan M., Holt P. G. Development of the airway intraepithelial dendritic cell network in the rat from class II major histocompatibility (Ia)-negative precursors: differential regulation of Ia expression at different levels of the respiratory tract. J Exp Med. 1994 Jan 1;179(1):203–212. doi: 10.1084/jem.179.1.203. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Nossal G. J. Cellular mechanisms of immunologic tolerance. Annu Rev Immunol. 1983;1:33–62. doi: 10.1146/annurev.iy.01.040183.000341. [DOI] [PubMed] [Google Scholar]
  24. Piccinni M. P., Mecacci F., Sampognaro S., Manetti R., Parronchi P., Maggi E., Romagnani S. Aeroallergen sensitization can occur during fetal life. Int Arch Allergy Immunol. 1993;102(3):301–303. doi: 10.1159/000236541. [DOI] [PubMed] [Google Scholar]
  25. Romagnani S. Regulation and deregulation of human IgE synthesis. Immunol Today. 1990 Sep;11(9):316–321. doi: 10.1016/s0167-5699(10)80004-0. [DOI] [PubMed] [Google Scholar]
  26. Schon-Hegrad M. A., Oliver J., McMenamin P. G., Holt P. G. Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatibility complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways. J Exp Med. 1991 Jun 1;173(6):1345–1356. doi: 10.1084/jem.173.6.1345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Singh R. R., Hahn B. H., Sercarz E. E. Neonatal peptide exposure can prime T cells and, upon subsequent immunization, induce their immune deviation: implications for antibody vs. T cell-mediated autoimmunity. J Exp Med. 1996 Apr 1;183(4):1613–1621. doi: 10.1084/jem.183.4.1613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Strobel S., Ferguson A. Immune responses to fed protein antigens in mice. 3. Systemic tolerance or priming is related to age at which antigen is first encountered. Pediatr Res. 1984 Jul;18(7):588–594. doi: 10.1203/00006450-198407000-00004. [DOI] [PubMed] [Google Scholar]
  29. Telemo E., Jakobsson I., Weström B. R., Folkesson H. Maternal dietary antigens and the immune response in the offspring of the guinea-pig. Immunology. 1987 Sep;62(1):35–38. [PMC free article] [PubMed] [Google Scholar]
  30. Upham J. W., Holt B. J., Baron-Hay M. J., Yabuhara A., Hales B. J., Thomas W. R., Loh R. K., O'Keeffe P. T., Palmer L., Le Souef P. N. Inhalant allergen-specific T-cell reactivity is detectable in close to 100% of atopic and normal individuals: covert responses are unmasked by serum-free medium. Clin Exp Allergy. 1995 Jul;25(7):634–642. doi: 10.1111/j.1365-2222.1995.tb01111.x. [DOI] [PubMed] [Google Scholar]
  31. Warner J. A., Miles E. A., Jones A. C., Quint D. J., Colwell B. M., Warner J. O. Is deficiency of interferon gamma production by allergen triggered cord blood cells a predictor of atopic eczema? Clin Exp Allergy. 1994 May;24(5):423–430. doi: 10.1111/j.1365-2222.1994.tb00930.x. [DOI] [PubMed] [Google Scholar]
  32. Whitacre C. C., Gienapp I. E., Orosz C. G., Bitar D. M. Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy. J Immunol. 1991 Oct 1;147(7):2155–2163. [PubMed] [Google Scholar]
  33. Wierenga E. A., Snoek M., de Groot C., Chrétien I., Bos J. D., Jansen H. M., Kapsenberg M. L. Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic patients. J Immunol. 1990 Jun 15;144(12):4651–4656. [PubMed] [Google Scholar]
  34. Young C. R., Atassi M. Z. T-lymphocyte recognition of sperm-whale myoglobin. Specificity of T-cell recognition following neonatal tolerance with either myoglobin or synthetic peptides of an antigenic site. J Immunogenet. 1983 Apr;10(2):161–169. doi: 10.1111/j.1744-313x.1983.tb01028.x. [DOI] [PubMed] [Google Scholar]
  35. Yu M., Fredrikson S., Link J., Link H. High numbers of autoantigen-reactive mononuclear cells expressing interferon-gamma (IFN-gamma), IL-4 and transforming growth factor-beta (TGF-beta) are present in cord blood. Clin Exp Immunol. 1995 Jul;101(1):190–196. doi: 10.1111/j.1365-2249.1995.tb02297.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Zhang Z. Y., Michael J. G. Orally inducible immune unresponsiveness is abrogated by IFN-gamma treatment. J Immunol. 1990 Jun 1;144(11):4163–4165. [PubMed] [Google Scholar]

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