Table 4.
Microarray results of intestinal genes down-regulated, under fructose perfusion only, in 20 d relative to those in 10-d-old pups
| Access no. | Symbol | Name and function | Mean fold change 20 vs. 10F | se | Frequency |
|---|---|---|---|---|---|
| Metabolism activity | |||||
| M18769 | Siat1 | Sialyltransferase 1 | −4.00 | 1.92 | 5 |
| U13617 | Z49858 | Plasmolipin | −3.13 | 0.59 | 5 |
| NM_012682 | Ucp1 | Uncoupling protein 1 | −1.82 | 0.79 | 4 |
| NM_19333 | Pfkfb4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | −1.64 | 0.40 | 4 |
| NM_017006 | G6pdx | Glucose-6-phosphate dehydrogenase | −1.56 | 0.24 | 4 |
| Transcription regulation activity/transcription factor | |||||
| NM_012639 | Raf1 | Murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV) | −1.92 | 0.18 | 5 |
| U56241 | Mafb | v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) | −1.61 | 0.60 | 4 |
| AF286534 | Rab11b | RAB11B, member RAS oncogene family | −1.61 | 0.23 | 4 |
| Signal transduction activity | |||||
| D87336 | Blmh | Bleomycin hydrolase | −5.00 | 4.75 | 5 |
| U73184 | Sdc3 | Syndecan 3 | −2.44 | 0.59 | 5 |
| NM_012649 | Sdc4 | Syndecan 4 | −1.69 | 0.26 | 4 |
| Development/proliferation/differentiation | |||||
| U69279 | Efna5 | eph-related receptor tyrosine kinase ligand 7 | −3.85 | 1.63 | 5 |
| U61261 | Lama3 | Laminin 5 α 3 | −1.96 | 0.77 | 4 |
| X81448 | Krt1–18 | Keratin complex 1, acidic, gene 18 | −1.85 | 0.51 | 4 |
| AF017637 | Cpz | Carboxypeptidase Z | −1.75 | 0.71 | 4 |
| X77934 | Aplp2 | Amyloid β (A4) precursor-like protein 2 | −1.72 | 0.15 | 5 |
| Transport | |||||
| NM_019229 | Slc12a4 | Solute carrier family 12, member 4 | −1.96 | 0.81 | 4 |
| Immune activity | |||||
| AJ271303 | Birc1 | Baculoviral IAP repeat-containing 1 | −1.85 | 0.65 | 5 |
| AJ006070 | Rag1 | Recombination activation protein 1 | −1.59 | 0.18 | 4 |
| Unclassified | |||||
| L01122 | Ftl1 | Ferritin light chain 1 | −1.75 | 0.09 | 5 |
| NM_017188 | Uncl19 | UNC-119 homolog (C. elegans) | −1.75 | 0.25 | 5 |
| S74323 | Clone E5103, estrogen-induced gene | −1.75 | 0.28 | 4 |
Down-regulated genes must have changed by more than 1.5-fold in at least four of five samples, and the fold change must be significantly different (P < 0.05). Values are mean ± se for each gene (n = 5). Negative values indicate the fold decrease in the expression of a gene in 20-d-old compared with 10-d-old fructose-perfused intestine.