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. Author manuscript; available in PMC: 2008 Dec 19.
Published in final edited form as: Neuroscience. 2007 Oct 5;150(4):807–817. doi: 10.1016/j.neuroscience.2007.09.060

Figure 6. Effect of deltorphin II on motor functions in MOR-KO mice.

Figure 6

Rotarod performances were evaluated following intrathecal injection of deltorphin II (2.5μg) to MOR-KO (●) and their littermate controls (MOR+/+, ○). Mean performance before deltorphin injection corresponds to the mean performance of mice from both groups (MOR-KO and littermates) before treatment. No significant difference was observed between performances before injection of deltorphin II. Intrathecal injection of deltorphin II induced similar motor uncoordination/ataxia-like behavior (*, p < 0.05 and **, p < 0.01 when compared with the mean performance before deltorphin II injection; one-way ANOVA followed by Dunnett’s multiple comparison test) in both groups of mice (p > 0.05 when comparing MOR-KO with littermate controls, two-way ANOVA followed by Bonferroni’s multiple comparison test). Number in parenthesis indicates the number of animals in each group.