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. 1960 Jul 1;43(6):1119–1136. doi: 10.1085/jgp.43.6.1119

Calcium and Strontium in Rat Small Intestine Their Fluxes and Their Effect on Na Flux

P A Dumont 1, Peter F Curran 1, A K Solomon 1
PMCID: PMC2195061  PMID: 13818612

Abstract

Studies have been carried out on movements of Ca and Sr ions in rat small intestine, using the in vivo preparation developed by Curran and Solomon (5). In the concentration range of 0 to 25 mM, Sr flux appears to be passive, though restricted. Ca transport may not, however, be ascribed to passive independent movement of these ions since at higher concentrations (12.5 and 25 mM) Ca return from blood to intestinal lumen increases more than expected. An apparent diffusion coefficient of Ca and Sr ions in the membrane has been calculated and the influence of negative charges within the membrane on cation diffusion has been examined in a semiquantitative manner. Both Ca and Sr ions exercise a drastic effect on active Na absorption from intestine and on concomitant passive water movement. From 0 to 1 mM, Ca and Sr ions cause a sharp increase in Na and water efflux from the lumen. This rising phase is interpreted in terms of combination of the divalent cation with the Na carrier system following Michaelis-Menten kinetics. At concentrations higher than 1 mM, the effect of Ca and Sr ions is reversed and Na and water absorption decreases slowly as Ca or Sr concentration is increased. This falling phase is ascribed to a non-specific Ca effect which produces a general "stiffening" of the membrane.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ATKINSON R. M., PARSONS B. J., SMYTH D. H. The intestinal absorption of glucose. J Physiol. 1957 Mar 11;135(3):581–589. doi: 10.1113/jphysiol.1957.sp005732. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BRINK F. The role of calcium ions in neural processes. Pharmacol Rev. 1954 Sep;6(3):243–298. [PubMed] [Google Scholar]
  3. CURRAN P. F., SCHWARTZ G. F. Na, Cl, and water transport by rat colon. J Gen Physiol. 1960 Jan;43:555–571. doi: 10.1085/jgp.43.3.555. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. CURRAN P. F., SOLOMON A. K. Ion and water fluxes in the ileum of rats. J Gen Physiol. 1957 Sep 20;41(1):143–168. doi: 10.1085/jgp.41.1.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. FRANKENHAEUSER B., HODGKIN A. L. The action of calcium on the electrical properties of squid axons. J Physiol. 1957 Jul 11;137(2):218–244. doi: 10.1113/jphysiol.1957.sp005808. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HARRISON G. E., RAYMOND W. H., TRETHEWAY H. C. The metabolism of strontium in man. Clin Sci. 1955 Nov;14(4):681–695. [PubMed] [Google Scholar]
  7. KOEFOED-JOHNSEN V., USSING H. H. The nature of the frog skin potential. Acta Physiol Scand. 1958 Jun 2;42(3-4):298–308. doi: 10.1111/j.1748-1716.1958.tb01563.x. [DOI] [PubMed] [Google Scholar]
  8. NICOLAYSEN R., EEG-LARSEN N., MALM O. J. Physiology of calcium metabolism. Physiol Rev. 1953 Jul;33(3):424–444. doi: 10.1152/physrev.1953.33.3.424. [DOI] [PubMed] [Google Scholar]
  9. Robinson C. V. Windowless, Flow Type, Proportional Counter for Counting C14. Science. 1950 Aug 18;112(2903):198–199. doi: 10.1126/science.112.2903.198. [DOI] [PubMed] [Google Scholar]
  10. SCHACHTER D., ROSEN S. M. Active transport of Ca45 by the small intestine and its dependence on vitamin D. Am J Physiol. 1959 Feb;196(2):357–362. doi: 10.1152/ajplegacy.1959.196.2.357. [DOI] [PubMed] [Google Scholar]

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