Abstract
The resting and action potentials of the m. gastrocnemii of normal and dystrophic mice have been measured in vitro, under various conditions of the ionic environment. The observed effects are consistent with the view that, when equilibrium is established between internal and external ionic concentrations, the resting potential is determined very largely, and perhaps entirely, by the gradient of K ions. Action potentials are associated with a greatly increased Na conductance in this as in other excitable tissues. No differences in electrical activity between normal and dystrophic muscle cells could be established.
Full Text
The Full Text of this article is available as a PDF (457.1 KB).
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CONRAD J. T., GLASER G. H. A study of membrane resting and action potentials of dystrophic mammalian muscle. Effects of electrolyte alterations. Trans Am Neurol Assoc. 1959;84:170–172. [PubMed] [Google Scholar]
- CREESE R., SCHOLES N. W., WHALEN W. J. Resting potentials of diaphragm muscle after prolonged anoxia. J Physiol. 1958 Feb 17;140(2):301–317. doi: 10.1113/jphysiol.1958.sp005935. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HODGKIN A. L., KATZ B. The effect of sodium ions on the electrical activity of giant axon of the squid. J Physiol. 1949 Mar 1;108(1):37–77. doi: 10.1113/jphysiol.1949.sp004310. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HOLMAN M. E., JOHNSTONE B. M., SHAW F. H., SIMON S. E. The effect of changes of environment on the electrical and ionic pattern of muscle. J Gen Physiol. 1956 Nov 20;40(2):263–288. doi: 10.1085/jgp.40.2.263. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MOORE J. W., COLE K. S. Resting and action potentials of the squid giant axon in vivo. J Gen Physiol. 1960 May;43:961–970. doi: 10.1085/jgp.43.5.961. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TRAUTWEIN W., ZINK K., KAYSER K. Uber Membran- und Aktionspotentiale einzelner Fasern des Warmblüterskeletmuskels und ihre Veränderung bei der Ischämie. Pflugers Arch. 1953;257(1):20–34. doi: 10.1007/BF00363409. [DOI] [PubMed] [Google Scholar]