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. 1962 Mar 1;45(4):115–124. doi: 10.1085/jgp.45.4.115

Bacteriolytic Enzymes from Streptomycetes

A review

Maurice Welsch 1
PMCID: PMC2195212  PMID: 14006056

Abstract

A study of the bacteriolytic properties of streptomycetes has progressively uncovered the production by these microorganisms of a large number of different enzymes acting upon various bacterial constituents, especially on some of them located in the cell wall. Although the mechanism of the bacteriolysis is far from being completely elucidated at present, it can, however, be stated that, in two instances at least, it can be regarded as an osmotic explosion following upon the destruction of the structure responsible for the rigidity of the cell wall.

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Selected References

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  1. CASTERMANS A. Antigène O de Salmonella typhimurium et bactériolyse par les actinomycètes. C R Seances Soc Biol Fil. 1950 Sep;144(17-18):1250–1253. [PubMed] [Google Scholar]
  2. CASTERMANS A. Influence du phosphate et de la température sur la lyse des Salmonelles par l'actinomycétine. C R Seances Soc Biol Fil. 1955 Jan;149(1-2):204–206. [PubMed] [Google Scholar]
  3. CASTERMANS A. Obtention de greffons purement épidermiques par traitement de lambeaux cutanés avec l'actinomycétine. C R Seances Soc Biol Fil. 1956 May 28;150(1):224–226. [PubMed] [Google Scholar]
  4. GHUYSEN J. M., SALTON M. R. Acetylhexosamine compounds enzymically released from Micrococcus lysodeikticus cell walls. I. Isolation and composition of acetylhexosamine and acetylhexosamine-peptide complexes. Biochim Biophys Acta. 1960 Jun 3;40:462–472. doi: 10.1016/0006-3002(60)91387-1. [DOI] [PubMed] [Google Scholar]
  5. GOODER H., MAXTED W. R. Protoplasts of group A beta-haemolytic streptococci. Nature. 1958 Sep 20;182(4638):808–809. doi: 10.1038/182808b0. [DOI] [PubMed] [Google Scholar]
  6. KLINGE K. Das extrazelluläre bakteriolytische Fermentsystem der Streptomyceten. Arch Hyg Bakteriol. 1955 Dec;139(8):565–579. [PubMed] [Google Scholar]
  7. MCCARTY M. The lysis of group A hemolytic streptococci by extracellular enzymes of Streptomyces albus. II. Nature of the cellular substrate attacked by the lytic enzymes. J Exp Med. 1952 Dec;96(6):569–580. doi: 10.1084/jem.96.6.569. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. SALTON M. R. J. Cell wall of Micrococcus lysodeikticus as the substrate of lysozyme. Nature. 1952 Nov 1;170(4331):746–747. doi: 10.1038/170746a0. [DOI] [PubMed] [Google Scholar]
  9. SALTON M. R. An improved method for the detection of N-acetylamino sugars on paper chromatograms. Biochim Biophys Acta. 1959 Aug;34:308–312. doi: 10.1016/0006-3002(59)90284-7. [DOI] [PubMed] [Google Scholar]
  10. SALTON M. R., GHUYSEN J. M. The structure of di- and tetrasaccharides released from cell walls by lysozyme and Streptomyces F 1 enzyme and the beta(1 to 4) N-acetylhexos-aminidase activity of these enzymes. Biochim Biophys Acta. 1959 Dec;36:552–554. doi: 10.1016/0006-3002(59)90205-7. [DOI] [PubMed] [Google Scholar]
  11. SALTON M. R. Isolation of Streptomyces spp. capable of decomposing preparations of cell walls from various micro-organisms and a comparison of their lytic activities with those of certain actinomycetes and myxobacteria. J Gen Microbiol. 1955 Feb;12(1):25–30. doi: 10.1099/00221287-12-1-25. [DOI] [PubMed] [Google Scholar]
  12. SLADE H. D., SLAMP W. C. Studies on Streptococcus pyogenes. V. Biochemical and microscopic aspects of cell lysis and digestion by enzymes from Streptomyces albus. J Bacteriol. 1960 Jan;79:103–112. doi: 10.1128/jb.79.1.103-112.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. SMOLIAR V. Influence des sels minéraux sur la formation du halo au cours de la bactériolyse par les actinomycètes. C R Seances Soc Biol Fil. 1950 Sep;144(17-18):1256–1258. [PubMed] [Google Scholar]
  14. SWERTZ L. Etude de l'activité bactériolytique des actinomycètes et particulièrement des phénomènes de halo. Rev Belg Pathol Med Exp. 1949 Sep;19(4):214–224. [PubMed] [Google Scholar]
  15. TAI T. Y., van HEYNINGEN W. E. Bacteriolysis by a species of Streptomyces. J Gen Microbiol. 1951 Feb;5(1):110–120. doi: 10.1099/00221287-5-1-110. [DOI] [PubMed] [Google Scholar]
  16. WEIBULL C. The isolation of protoplasts from Bacillus megaterium by controlled treatment with lysozyme. J Bacteriol. 1953 Dec;66(6):688–695. doi: 10.1128/jb.66.6.688-695.1953. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. WELSCH M. Activites Bactériolytiques des Microorganismes. Ergeb Mikrobiol Immunitatsforsch Exp Ther. 1957;30:217–279. [PubMed] [Google Scholar]
  18. WELSCH M. Activités staphylolytique et streptolytique des filtrats de culture de Streptomyces spp. C R Seances Soc Biol Fil. 1954 Mar;148(5-6):604–606. [PubMed] [Google Scholar]
  19. WELSCH M., DELCAMBE L. Recherches sur la libération de phosphore et d'azote au cours de l'autolyse staphylococcique. Bull Soc Chim Biol (Paris) 1951;33(5-6):488–504. [PubMed] [Google Scholar]
  20. WELSCH M., GHUYSEN J. M. Activité streptolytique de l'actinomycétine. C R Seances Soc Biol Fil. 1953 Oct;147(19-20):1659–1662. [PubMed] [Google Scholar]
  21. WELSCH M. Lysis by agents of microbial origin. J Gen Microbiol. 1958 Apr;18(2):491–497. doi: 10.1099/00221287-18-2-491. [DOI] [PubMed] [Google Scholar]
  22. WELSCH M. Production de protoplastes d'Escherichia coli sous l'influence de la glycine en milieu saccharosé. C R Seances Soc Biol Fil. 1957;151(11):1990–1993. [PubMed] [Google Scholar]
  23. WELSCH M., SALMON J. Quelques aspects de la staphylolyse. Ann Inst Pasteur (Paris) 1950 Nov;79(5):802–813. [PubMed] [Google Scholar]
  24. WELSCH M. Transformation en sphéroplastes et lyse d'Escherichia coli par l'actinomycétine. C R Seances Soc Biol Fil. 1959;153(2):370–372. [PubMed] [Google Scholar]
  25. WELSCH M. [Bacterial structure and bacteriolytic activity of certain antibiotics]. Bull Acad R Med Belg. 1960;25:117–159. [PubMed] [Google Scholar]
  26. WORK E. Biochemistry of the bacterial cell wall. Nature. 1957 Apr 27;179(4565):841–847. doi: 10.1038/179841a0. [DOI] [PubMed] [Google Scholar]
  27. Welsch M. Actinomycetin. J Bacteriol. 1947 Jan;53(1):101–102. [PMC free article] [PubMed] [Google Scholar]
  28. Welsch M. Bacteriolytic Properties of Actinomyces. J Bacteriol. 1941 Dec;42(6):801–814. doi: 10.1128/jb.42.6.801-814.1941. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Welsch M. Bacteriostatic and Bacteriolytic Properties of Actinomycetes. J Bacteriol. 1942 Nov;44(5):571–588. doi: 10.1128/jb.44.5.571-588.1942. [DOI] [PMC free article] [PubMed] [Google Scholar]

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