Abstract
The development of isometric twitch tension has been compared with the redevelopment of isometric tension in the fully active frog sartorius muscle following release. At 0°C the rate of rise of isometric twitch tension is the same as that for the muscle in the fully active state at the same tension but not until about 40 msec. after the stimulus and then only for a few milliseconds. The rates of rise of tension in the twitch and in the redevelopment of tension in the fully active muscle appear to be nearly the same at low tensions. Substitution of nitrate for chloride in the Ringer's solution bathing the muscle retards the development of tension during the early part of the contraction phase of the twitch and the effect reaches a maximum within 3 minutes after changing the solutions. These observations have been discussed in connection with some possible patterns of activation and the hypothesis has been advanced that the rate of activation of a sarcomere is determined mainly by the rate at which the transverse component of the link between excitation and contraction is propagated inwards from the periphery to the center of the fiber. This hypothesis has been discussed in relation to others concerning the nature of excitation-contraction coupling.
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Selected References
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- ABBOTT B. C., AUBERT X. M. The force exerted by active striated muscle during and after change of length. J Physiol. 1952 May;117(1):77–86. [PMC free article] [PubMed] [Google Scholar]
- ABBOTT B. C., RITCHIE J. M. The onset of shortening in striated muscle. J Physiol. 1951 Apr;113(2-3):336–345. doi: 10.1113/jphysiol.1951.sp004577. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BUCHTHAL F., STEN-KNUDSEN O. Impulse propagation in striated muscle fibers and the role of the internal currents in activation. Ann N Y Acad Sci. 1959 Aug 28;81:422–445. doi: 10.1111/j.1749-6632.1959.tb49325.x. [DOI] [PubMed] [Google Scholar]
- CSAPO A., SUZUKI T. The effectiveness of the longitudinal field, coupled with depolarization in activating frog twitch muscles. J Gen Physiol. 1958 May 20;41(5):1083–1098. doi: 10.1085/jgp.41.5.1083. [DOI] [PMC free article] [PubMed] [Google Scholar]
- CSAPO A. Studies on excitation-contraction coupling. Ann N Y Acad Sci. 1959 Aug 28;81:453–467. doi: 10.1111/j.1749-6632.1959.tb49327.x. [DOI] [PubMed] [Google Scholar]
- FRANK G. B. Inward movement of calcium as a link between electrical and mechanical events in contraction. Nature. 1958 Dec 27;182(4652):1800–1801. doi: 10.1038/1821800a0. [DOI] [PubMed] [Google Scholar]
- GELFAN S. Muscle. Annu Rev Physiol. 1958;20:67–96. doi: 10.1146/annurev.ph.20.030158.000435. [DOI] [PubMed] [Google Scholar]
- Gelfan S. The submaximal responses of the single muscle fibre. J Physiol. 1933 Dec 30;80(3):285–295. doi: 10.1113/jphysiol.1933.sp003089. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HILL A. V. The abrupt transition from rest to activity in muscle. Proc R Soc Lond B Biol Sci. 1949 Oct;136(884):399–420. doi: 10.1098/rspb.1949.0033. [DOI] [PubMed] [Google Scholar]
- HILL A. V. The mechanics of active muscle. Proc R Soc Lond B Biol Sci. 1953 Mar 11;141(902):104–117. doi: 10.1098/rspb.1953.0027. [DOI] [PubMed] [Google Scholar]
- HODGKIN A. L., HOROWICZ P. The effect of nitrate and other anions on the mechanical response of single muscle fibres. J Physiol. 1960 Sep;153:404–412. doi: 10.1113/jphysiol.1960.sp006542. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HUXLEY A. F. Local activation of muscle. Ann N Y Acad Sci. 1959 Aug 28;81:446–452. doi: 10.1111/j.1749-6632.1959.tb49326.x. [DOI] [PubMed] [Google Scholar]
- KAHN A. J., SANDOW A. The potentiation of muscular contraction by the nitrate-ion. Science. 1950 Dec 1;112(2918):647–649. doi: 10.1126/science.112.2918.647. [DOI] [PubMed] [Google Scholar]
- MACPHERSON L., WILKIE D. R. The duration of the active state in a muscle twitch. J Physiol. 1954 May 28;124(2):292–299. doi: 10.1113/jphysiol.1954.sp005107. [DOI] [PMC free article] [PubMed] [Google Scholar]
- PORTER K. R., PALADE G. E. Studies on the endoplasmic reticulum. III. Its form and distribution in striated muscle cells. J Biophys Biochem Cytol. 1957 Mar 25;3(2):269–300. doi: 10.1083/jcb.3.2.269. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SANDOW A. Excitation-contraction coupling in muscular response. Yale J Biol Med. 1952 Dec;25(3):176–201. [PMC free article] [PubMed] [Google Scholar]
- STEN-KNUDSEN O. Is muscle contraction initiated by internal current flow? J Physiol. 1960 May;151:363–384. doi: 10.1113/jphysiol.1960.sp006444. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STEN-KNUDSEN O. The ineffectiveness of the `window field' in the initiation of muscle contraction. J Physiol. 1954 Aug 27;125(2):396–404. doi: 10.1113/jphysiol.1954.sp005167. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WATANABE A. Initiation of contraction by transverse and longitudinal current flow in single muscle fibers. Jpn J Physiol. 1958 Jun 15;8(2):123–137. doi: 10.2170/jjphysiol.8.123. [DOI] [PubMed] [Google Scholar]