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. 1964 Jul 1;47(6):1043–1059. doi: 10.1085/jgp.47.6.1043

Ion Transport in Isolated Rabbit Ileum

II. The interaction between active sodium and active sugar transport

Stanley G Schultz 1, Ralph Zalusky 1
PMCID: PMC2195378  PMID: 14192544

Abstract

The addition of actively transported sugars to the solution bathing the mucosal surface of an in vitro preparation of distal rabbit ileum results in a rapid increase in the transmural potential difference, the short-circuit current, and the rate of active Na transport from mucosa to serosa. These effects are dependent upon the active transport of the sugar per se and are independent of the metabolic fate of the transported sugar. Furthermore, they are inhibited both by low concentrations of phlorizin in the mucosal solution and by low concentrations of ouabain in the serosal solution. The increase in the short-circuit current, ΔIsc, requires the presence of Na in the perfusion medium and its magnitude is a linear function of the Na concentration. On the other hand, ΔIsc is a saturable function of the mucosal sugar concentration which is consistent with Michaelis-Menten kinetics suggesting that the increase in active Na transport is stoichiometrically related to the rate of active sugar transport. An interpretation of these findings in terms of a hypothetical model for intestinal Na and sugar transport is presented.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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