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. 1964 Nov 1;48(2):323–335. doi: 10.1085/jgp.48.2.323

The Effect of Electrotonus on the Olfactory Epithelium

Shoji Higashino 1, Sadayuki F Takagi 1
PMCID: PMC2195419  PMID: 14225260

Abstract

The effect of electrotonus on the slow potential of the olfactory epithelium of the frog was studied. The "on"-slow potential induced by a general odor like amyl acetate increased its magnitude in accordance with increase of anodal current, while it decreased its magnitude with increase of cathodal current. Similar relations were also found in the case of the vapors of organic solvents like ethyl ether of low concentrations. Conversely, the on-slow potential induced by the vapors of organic solvents of high concentration decreased its magnitude in accordance with the increase of anodal current, while it increased its magnitude with the increase of cathodal current. The "off"-slow potential induced by the vapors of organic solvents of high concentration showed a potential change under the action of electrotonic currents which is similar to the change of the on-slow potential induced by general odors. It was concluded that there are two receptive processes in the olfactory cell. One is an ordinary excitatory process which produces an electronegative slow potential in response to general odors. The other is a process of a different kind which is activated only by the vapor of an organic solvent of high concentration and which shows an entirely opposite reaction from that generally found in excitable tissues when an electrotonic current is applied.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COOMBS J. S., ECCLES J. C., FATT P. Excitatory synaptic action in motoneurones. J Physiol. 1955 Nov 28;130(2):374–395. doi: 10.1113/jphysiol.1955.sp005413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. COOMBS J. S., ECCLES J. C., FATT P. The specific ionic conductances and the ionic movements across the motoneuronal membrane that produce the inhibitory post-synaptic potential. J Physiol. 1955 Nov 28;130(2):326–374. doi: 10.1113/jphysiol.1955.sp005412. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. FATT P., KATZ B. An analysis of the end-plate potential recorded with an intracellular electrode. J Physiol. 1951 Nov 28;115(3):320–370. doi: 10.1113/jphysiol.1951.sp004675. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. HIGASHINO S., TAKAGI S. F., YAJIMA M. The olfactory stimulating effectiveness of homologous series of substances studied in the frog. Jpn J Physiol. 1961 Oct 15;11:530–544. doi: 10.2170/jjphysiol.11.530. [DOI] [PubMed] [Google Scholar]
  5. KUFFLER S. W., EYZAGUIRRE C. Synaptic inhibition in an isolated nerve cell. J Gen Physiol. 1955 Sep 20;39(1):155–184. doi: 10.1085/jgp.39.1.155. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. LOEWENSTEIN W. R., ISHIKO N. Effects of polarization of the receptor membrane and of the first Ranvier node in a sense organ. J Gen Physiol. 1960 May;43:981–998. doi: 10.1085/jgp.43.5.981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MOZELL M. M. Olfactory mucosal and neural responses in the frog. Am J Physiol. 1962 Aug;203:353–358. doi: 10.1152/ajplegacy.1962.203.2.353. [DOI] [PubMed] [Google Scholar]
  8. OTTOSON D. Comparison of slow potentials evoked in the frog's nasal mucosa and olfactory bulb by natural stimulation. Acta Physiol Scand. 1959 Nov 15;47:149–159. doi: 10.1111/j.1748-1716.1960.tb00065.x. [DOI] [PubMed] [Google Scholar]
  9. OTTOSON D. Studies on slow potentials in the rabbit's olfactory bulb and nasal mucosa. Acta Physiol Scand. 1959 Nov 15;47:136–148. doi: 10.1111/j.1748-1716.1960.tb00064.x. [DOI] [PubMed] [Google Scholar]
  10. OTTOSON D. Studies on the relationship between olfactory stimulating effectiveness and physico-chemical properties of odorous compounds. Acta Physiol Scand. 1958 Aug 25;43(2):167–181. doi: 10.1111/j.1748-1716.1958.tb01585.x. [DOI] [PubMed] [Google Scholar]
  11. OTTOSON D. Sustained potentials evoked by olfactory stimulation. Acta Physiol Scand. 1954 Dec 31;32(4):384–386. doi: 10.1111/j.1748-1716.1954.tb01186.x. [DOI] [PubMed] [Google Scholar]
  12. SHIBUYA T., TAKAGI S. F. ELECTRICAL RESPONSE AND GROWTH OF OLFACTORY CILIA OF THE OLFACTORY EPITHELIUM OF THE NEWT IN WATER AND ON LAND. J Gen Physiol. 1963 Sep;47:71–82. doi: 10.1085/jgp.47.1.71. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. SHIBUYA T. The electrical responses of the olfactory epithelium of some fishes. Jpn J Physiol. 1960 Jun 29;10:317–326. doi: 10.2170/jjphysiol.10.317. [DOI] [PubMed] [Google Scholar]
  14. TAKAGI S. F., SHIBUYA T., HIGASHINO S., ARAI T. The stimulative and anaesthetic actions of ether on the olfactory epithelium of the frog and the toad. Jpn J Physiol. 1960 Dec 15;10:571–584. doi: 10.2170/jjphysiol.10.571. [DOI] [PubMed] [Google Scholar]
  15. TAKAGI S. F., SHIBUYA T. Potential oscillations in the lower olfactory pathway of the toad. Nature. 1960 May 28;186:724–724. doi: 10.1038/186724a0. [DOI] [PubMed] [Google Scholar]
  16. TAKAGI S. F., SHIBUYA T. Studies on the potential oscillation appearing in the olfactory epithelium of the toad. Jpn J Physiol. 1961 Feb 15;11:23–37. doi: 10.2170/jjphysiol.11.23. [DOI] [PubMed] [Google Scholar]
  17. TAKAGI S. F., SHIBUYA T. The electrical activity of the olfactory epithelium studied with micro- and macro-electrodes. Jpn J Physiol. 1960 Aug 15;10:385–395. doi: 10.2170/jjphysiol.10.385. [DOI] [PubMed] [Google Scholar]
  18. TAKAGI S. F., SHIBUYA T. The potential oscillations observed in the olfactory epithelium, nerve and bulb of the toad and frog. Jpn J Physiol. 1960 Oct 15;10:499–508. doi: 10.2170/jjphysiol.10.499. [DOI] [PubMed] [Google Scholar]
  19. TAKAGI S. F., YAJIMA T. ELECTRICAL RESPONSES TO ODOURS OF DEGENERATING OLFACOTRY EPITHELIUM. Nature. 1964 Jun 20;202:1220–1220. doi: 10.1038/2021220a0. [DOI] [PubMed] [Google Scholar]
  20. TAKEUCHI A., TAKEUCHI N. On the permeability of end-plate membrane during the action of transmitter. J Physiol. 1960 Nov;154:52–67. doi: 10.1113/jphysiol.1960.sp006564. [DOI] [PMC free article] [PubMed] [Google Scholar]

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