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. 1966 Mar 1;49(4):629–640. doi: 10.1085/jgp.49.4.629

Analysis of K Inactivation and TEA Action in the Supramedullary Cells of Puffer

Shigehiro Nakajima 1
PMCID: PMC2195516  PMID: 5943605

Abstract

Under the voltage clamp condition, the K inactivation was analyzed in cells bathed in the isosmotic KCl Lophius-Ringer solution. After conditioning hyperpolarization, the cells respond to depolarizations with increased K permeability, which in turn is decreased during maintained depolarizations. The steady-state levels of the K inactivation as a function of the membrane potential are related by an S-shaped curve similar to that which describes the steady-state Na inactivation in the squid giant axon. TEA reduced the K conductance by a factor which is independent of the potential, and without a shift of the inactivation curve along the voltage axis. The rapid phase of the K activation is less susceptible to TEA than the slow phase of the K activation. Hyperpolarizing steps remove the K inactivation, the rate of the removal being faster the larger the hyperpolarization from the standard potential of about -60 mv.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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