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. Author manuscript; available in PMC: 2009 Jan 5.
Published in final edited form as: Virology. 2007 Sep 29;370(1):184–193. doi: 10.1016/j.virol.2007.08.011

Figure 4. Infectivity and Replication of Cl8-RTK412E.

Figure 4

(A) The infectivity of RT mutant, Cl8-RTK412E, was compared to the parental virus, SIVmneCl8, and chimeric virus 8/027pol using the sMAGI infectivity assay as described (Patel et al., 2002). Infections were carried out in triplicate. The average numbers of infected cells per ng p27 ± SD are shown. One representative of four independent experiments is shown. (B) Replication of the mutant Cl8-RTK412E in pig-tailed macaque CD4+ T cells after costimulation with anti-CD3/anti-CD28 monoclonal antibodies. The average p27 levels ± SD are shown and the data are representative of independent experiments using cells from two different pig-tailed macaque donors.