There was an error in Table . The correct version appears below.
Table 1.
Tight Junction Proteins
| TJ proteins | Structural features | Function | Known partners |
|---|---|---|---|
| Claudins | 4 TM, COOH-YV | TJ barrier | ZO-11 |
| Occludin | 4 TM | TJ barrier | ZO-1, ZO-2, Vap33, actin1–3 |
| JAM | 1 TM, Ig-like | Monocyte transmigration4 | |
| ZO-1 | 3 PDZ, 1SH3, GUK | Scaffold protein, signaling molecule | Occludin, claudins, ZO-2, -3, cingulin, actin, ZONAB1,2,5,6 |
| ZO-2 | 3 PDZ, 1SH3, GUK | Scaffold protein | ZO-1, actin2 |
| ZO-3 | 3 PDZ, 1SH3, GUK | Scaffold protein | ZO-1, occludin2 |
| AF-6 | PDZ | Scaffold protein | Ras, ZO-17 |
| Dlg (Drosophila) | 3 PDZ, 1SH3, GUK | Scaffold protein, signaling molecule8 | |
| Scribble (Drosophila) | 4 PDZ | Fence/membrane traffic9 | |
| Cingulin | coiled coil | ZO-1, -2, -3, occludin, myosin5 | |
| Symplekin | Signaling molecule10 | ||
| ASIP/Par3 | 3 PDZ | Signaling molecule | PKC ζ11,12,13 |
| Rab3b | GDP/GTP binding | Membrane traffic14 | |
| Rab13 | GDP/GTP binding | Membrane traffic | δ-PDE15,16 |
| Rab8 | GDP/GTP binding | Membrane traffic | G/C kinase17,18 |
| Sec6, Sec8 | Vesicle docking | Exocyst subunits19 |
Exponent numbers indicate references: 1, Itoh et al., 1999; 2, Wittchen et al., 1999; 3, Lapierre et al., 1999; 4, Martin-Padura et al., 1998; 5, Cordenonsi et al., 1999; 6, Balda and Matter, 2000; 7, Yamamoto et al., 1997; 8, Woods and Bryant, 1991; 9, Bilder and Perrimon, 2000a; 10, Keon et al., 1996; 11, Joberty et al., 2000; 12, Lin et al., 2000; 13, Izumi et al., 1998; 14, Weber et al., 1994; 15, Zahraoui et al., 1994; 16, Marzesco et al., 1998; 17, Huber et al., 1993; 18, Ren et al., 1996; and 19, Grindstaff et al., 1998.